二甲双胍联合去氧孕烯炔雌醇片配合中药组方治疗子宫腺肌病的临床应用

摘要

ObjectiveTo investigate clinical application effect by metformin combined with desogestrel and ethinylestradiol tablets and traditional Chinese medicines formulas in the treatment of adenomyosis.Methods A total of 84 patients with adenomyosis were randomly divided into Western medicine group and Chinese and Western medicine group, with 42 cases in each group. The Western group received metformin combined with desogestrel and ethinylestradiol tablets for treatment, and the Chinese and Western medicine group received metformin combined with desogestrel and ethinylestradiol tablets and traditional Chinese medicines formulas for treatment. Comparison was made on total effective rate in treating adenomyosis, uterine volume before and after treatment, visual analogue scale (VAS) score, menstrual blood volume, 1-year pregnancy rate and recurrence rate between the two groups.ResultsThe Chinese and Western medicine group had obviously higher total effective rate in treating adenomyosis as 95.24% than 71.43% in the Western medicine group, and the difference had statistical significance (P<0.05). There was no statistically significant difference of uterine volume, VAS score and menstrual blood volume between the two groups before treatment (P>0.05). The Chinese and Western medicine group had uterine volume as (132.89±40.71) cm3, VAS score as (0.45±0.19) points and menstrual blood volume as (63.28±0.86) ml after treatment, which were all lower than (152.03±60.42) cm3, (2.56±0.76) points and (79.88±0.52) ml in the Western medicine group. Their difference had statistical significance (P<0.05). The Chinese and Western medicine group had much higher 1-year pregnancy rate as 50.00% than 23.81% in the Western medicine group, while its 1-year recurrence rate was much lower as 2.38% than 14.29% in the Western medicine group. Their difference had statistical significance (P<0.05).ConclusionCombination of metformin, desogestrel and ethinylestradiol tablets and traditional Chinese medicines formulas provide precise effect in treating adenomyosis. This method can effectively improve menstrual condition and uterine volume, relieve pain, increase pregnancy rate and reduce recurrence rate. It is worth promoting.%目的：探讨二甲双胍联合去氧孕烯炔雌醇片配合中药组方治疗子宫腺肌病的临床应用疗效。方法84例子宫腺肌病患者,随机分为西药组和中西药组,各42例。西药组采用二甲双胍联合去氧孕烯炔雌醇片治疗；中西药组采用二甲双胍联合去氧孕烯炔雌醇片配合中药组方治疗。比较两组患者子宫腺肌病治疗总有效率,治疗前后子宫体积、视觉模拟评分法(VAS)评分和月经量,1年受孕率和复发率。结果中西药组患者子宫腺肌病治疗总有效率为95.24%,显著高于西药组的71.43%,差异有统计学意义(P<0.05)。两组患者治疗前子宫体积、VAS评分和月经量比较,差异无统计学意义(P>0.05)；中西药组治疗后子宫体积为(132.89±40.71)cm3、VAS评分为(0.45±0.19)分、月经量为(63.28±0.86)ml,低于西药组的(152.03±60.42)cm3、(2.56±0.76)分、(79.88±0.52)ml,差异有统计学意义(P<0.05)。中西药组患者1年受孕率为50.00%,显著高于西药组的23.81%；1年复发率为2.38%,显著低于西药组的14.29%,差异有统计学意义(P<0.05)。结论二甲双胍联合去氧孕烯炔雌醇片配合中药组方治疗子宫腺肌病的临床效果确切,可有效改善患者月经情况和子宫体积,缓解疼痛,提高受孕率,降低复发率,值得推广。