28例药物不良反应死亡病例分析

摘要

目的：研究死亡病例的疾病分布与 28例药物不良反应致死因素，以提高疾病预防和用药的合理性及疗效。方法：采用微机网络系统对 2年来我院住院死亡患者按药物不良反应评估标准进行系统统计分析。结果：分析表明， 28例死亡患者直接为药物不良反应所致，最常见的致死药物为胰岛素和优降糖，占 32.14％；其次是甘露醇、硫唑嘌呤等药。从年龄结构分析，药物不良反应致死的老人占 63.28％。结论：（1）合理用药对降低老年性疾病死亡率有重要的临床意义。（2）详细询问病史，严格掌握用药指征和剂量，是防止药物不良反应致死的重要手段。%OBJECTIVE： To study the disease distribution and lethal factors of ADRs in 28 fatal cases,so as to improve the prophylactic measures for diseases and rationality and therapeutic effect of drug-use.METHODS： According to ADRs evaluation standard,the cases who died in this hospital in recent 2 years were analysed with computer internet.RESULTS： 28 cases directly died of ADRs.Insulin and glibenclamidium were the most common lethal agents,accounting for 32.14％ ,and mannitol and azathiopurine were the next ones.Senile patient accounted for 63.28％ of all patients died of ADRs.CONCLUSION： (1)Rational drug-use has clinical significance in reducing mortality of geratic diseases.(2)It will be an important way in reducing the fatality of ADRs that we inquire about patients' illness carefully and handle the indications and dosages of drugs seriously.