复方维甲酸霜的研制及其治疗黄褐斑疗效观察

摘要

OBJECTIVE:To prepare compound tretinoin cream No I,No II and observe their effects on chloasma.METHODS:The cream was prepared by taking tretinoin,kojoic acid and allantoin as main components and adding base material.The tretinoin was encapsulated with ?-cyclodextrin.RESULTS & CONCLUSION:The prescription of compound tretinoin cream is rational,preparation technic being stable and therapeutic effect on chloasma is satisfactory.%目的:制备复方维甲酸Ⅰ号、Ⅱ号，观察对黄褐斑的疗效。方法:以维甲酸、曲酸、尿囊素为主药，加基质制成，其中维甲酸用β-环状糊精包裹。结果与结论:复方维甲酸霜处方设计合理，工艺稳定，易于掌握；临床治疗黄褐斑疗效显著。