克拉霉素与红霉素治疗小儿呼吸道支原体感染的对比研究

摘要

OBJECTIVE：To compare the effect and adverse reactions of clarithromycin(Limaixian，CT)with those of erythromycin(ET)in treating respiratory tract mycoplasmal infections of children.METHODS：98 patients were randomly divided into CT group(56 cases)and ET group(42 cases)，CT in oral dosage of 20mg/(kg.d)and ET in iv dosage of 30～40mg/(kg· d)were given respectively.RESULTS：The curative rate，effective rate and clearance of mycoplasma of CT group were higher than those of ET group with significant differences(P<0.05).The adverse reactions induced by oral CT were less than those by iv infused ET(P<0.01).CONCLUSION： Oral CT shows satisfactory therapeutic effect， less adverse reactions and can effectively clear away mycoplasma in treatment of respiratory tract mycoplasmal infections of childhood.%目的：对比口服克拉霉素(利迈先)与静滴红霉素治疗小儿呼吸道支原体感染的疗效及副作用。方法：将98例病人随机分为克拉霉素组56例，红霉素组42例，分别应用克拉霉素20mg/(kg·d)，口服，或红霉素30～40mg/(kg·d)，静脉滴注。结果：克拉霉素组治愈率、有效率、支原体清除率均高于红霉素组，具有显著性差异(P<0.05）；口服克拉霉素副作用较静滴红霉素少（P<0.01）。结论：口服克拉霉素治疗小儿呼吸道支原体感染疗效确切，副作用少，且能有效清除肺炎支原体。