二氢－β－刺桐啶碱对交感神经元烟碱诱发电流的抑制作用

摘要

目的：观察二氢－β－刺桐啶碱对培养的新生大鼠颈上神经节细胞烟碱诱发电流的抑制作用。方法：用气压给药和膜片钳全细胞记录技术比较烟碱诱发电流幅度。结果：二氢－β－刺桐啶碱竞争性拮抗烟碱作用，其平衡解离常数约为0.015mmol/L。结论：二氢－β－刺桐啶碱是交感神经元烟碱受体的竞争性拮抗剂。%AIM： To investigate the inhibitory effect of dihydro－ β －erythroidine on nicotine induced－ current in cultured superior cervical ganglion of neonatal rats.METHODS： Pneumatic pressure administration of drug and whole－ cell recording techniques were performed to compare induced－ current amplitude.RESULTS： Dihydro－ β － erythroidine competitively antagonized nicotinic effect,and EC50 was about 0.015mmol/L.CONCLUSION： Dihydro－ β － erythroidine is a competitive antagonist of nicotinic receptors in sympathetic neurons.