甘露醇致不良反应文献分析

摘要

To study the general pattern and characteristics of the adverse drug reactions (ADR) induced by mannitol. METHODS: The literature related to the ADR induced by mannitol reported during 1999～2008 retrieved from CNKI was analyzed statistically. RESULTS: A total of 135 mannitol-induced ADR cases were collected, of which, males showed higher proportion than females, and the ADRs chiefly manifested as acute renal failure(30 cases,22.22%), followed by allergic reactions(17 cases, 12.59%) and shock(17 cases, 12.59%) . CONCLUSION: Clinicians should tighten monitoring on the use of mannitol to reduce the occurrence of mannitol-induced ADR.%目的:探讨甘露醇致不良反应的一般规律与特点.方法:检索1999～2008年甘露醇所致不良反应文献,并进行统计、分析.结果:甘露醇引起的不良反应共计135例,男性多于女性.所致不良反应最多为急性肾功能衰竭30例(22.22%),其次为过敏17例(12.59%)、休克17例(12.59%).结论:临床上应加强甘露醇应用的监测,以减少不良反应的发生.