我院312例药品不良反应报告分析

摘要

To probe into the characteristics and general pattern of the adverse drug reactions (ADR) in order to promote clinical rational drug use. METHODS: By a retrospective study, a total of 312 ADR cases collected from Oct. 1, 2002 to Dec. 31, 2008 in our hospital were analyzed in respect of patients' age and sex, drug varieties, route of administration, organs or system involved and the clinical manifestation, etc. RESULTS: Of the 312 ADR cases, 63.46% were induced by antibiotics versus 13.14% by traditional Chinese herbal injections; 86.86% were induced intravenously, 47.12% manifested as lesions of skin and its appendants. The ADRs were more often seen in patients aged above 70 years. CONCLUSION: Clinical rational use of antimicrobial drugs and the Chinese herbal injections as well as the monitoring on quality and standard use of the traditional Chinese herbal injections should be emphasized to avoid or decrease ADR incidence.%目的:了解我院药品不良反应(ADR)发生特点及一般规律,促进临床合理用药.方法:采用回顾性研究方法,对我院2002年10月1日～2008年12月31日收集的312例ADR报告分别从患者性别与年龄、药品种类、给药途径、累及器官或系统及临床表现等方面进行统计、分析.结果:312例ADR中,抗微生物药占63.46%,中药注射剂占13.14%.静脉给药引发的ADR例教最多,占86.86%;以皮肤及其附件损害最多,占47.12%.ADR多发于70岁以上人群.结论:临床应合理使用抗微生物药及中药注射剂,加强对中药注射剂的质量监测和规范使用,避免或减少ADR重复发生.