OBJECTIVE: To strengthen the re-cognition on propofol infusion syndrome. METHODS: Reviewing literatures in recent years, the advancement of propofol infusion syndrome were analyzed and summarized in respects of clinical manifestation, incidence, mortality, pathogenesis, influencing factors, diagnosis and prevention in the early stage. RESULTS: Propofol infusion syndrome was one of rare fatal adverse drug reactions. The pathogenesis of it was still not interpreted clearly. There were various influencing factors, complicate and flexible clinical manifestations. It was difficult to diagnose it in the early stage. At present, specific treatment measure hadn' t been found. CONCLUSION: The most effective prevention and treatment measures for propofol infusion syndrome are to avoid applying large-dose (>4 mg·kg-1·h-1) of propofol for a long time (48 h) to sedation.%目的:加强对异丙酚输注相关综合征的认识.方法:通过回顾最近几年的文献,分析与综合有关异丙酚输注相关综合征临床表现的演绎、发生率、死亡率、发病机制、影响因素以及早期诊断与防治等问题的新进展.结果:异丙酚输注相关综合征是一种少见的、致命性的药品不良反应.其发病机制尚未阐明,影响因素众多,临床表现复杂、多变,早期诊断困难,目前仍无特异性的治疗措施.结论:避免在易感人群中大剂量( ＞4 mg·kg-1·h-1)、长时间(48 h)使用异丙酚镇静是异丙酚输注相关综合征最有效的防治措施.
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