目的:通过检索泛耐药鲍曼不动杆菌(PDRAB)感染病例,分析不同抗菌药物的临床疗效,为临床治疗PDRAB感染提供参考.方法:以“泛耐药鲍曼不动杆菌”为关键词,在中国医院数字图书馆期刊全文数据库和万方数据库中检索1994-2011年发表的治疗PDRAB感染病例并进行分析.结果:检索到5篇论文,共196例.目前临床治疗PDRAB常用的抗菌药物为多粘菌素、头孢哌酮/舒巴坦、碳青霉烯类单用或联用其他抗菌药物.选择的药物剂量大多为中等剂量,疗程为2周左右.多粘菌素的临床有效率最高,可达80％以上；其次为头孢哌酮/舒巴坦,尤其是联用米诺环素时临床有效率达50％以上；美罗培南与其他抗菌药物联用的临床有效率达50％左右.结论:对于PDRAB引起的院内感染,首选多粘菌素,头孢哌酮/舒巴坦及美罗培南联用米诺环素等也有一定疗效.%OBJECTIVE: To retrieve medical cases of pandrug resistant Acinetobacter baumanii (PDRAB) infection, to analyze the clinical efficacy of different antibiotics, and to provide reference for effective treatment of PDRAB infection in the clinic. METHODS: By searching from CHKD-J and Wanfang database, using PDRAB as key word, the cases of PDRAB infection, which were published during 1994 - 2011, were collected and analyzed. RESULTS: A total of 5 literatures had been collected, including 196 patients. It was found that the colistin, cefoperazone/sulbactam and carbapenems were frequently selected in the clinic with medium doses for 2 weeks. The clinical effective rate of colistin was the highest and up to 80%, followed by cefoperazone/sulbactam, especially clinical effective rate of cefoperazone-sulbactam associated with minocycline was more than 50%. Meropenem combined with other antibiotics also produced good effective rate about 50%. CONCLUSIONS: For the management of PDRAB infection, colistin is the first choice. And cefoperazone/sulbactam or meropenem combined with minocycline may produce good effects.
展开▼
