十三味辛夷滴鼻剂抗炎和体外抑菌作用研究

摘要

目的:研究十三味辛夷滴鼻剂的抗炎和体外抑菌作用.方法:采用二甲苯致小鼠耳廓肿胀与乙酸致小鼠毛细血管通透性改变实验,观察十三味辛夷滴鼻剂的抗炎作用；用杯碟法测定十三味辛夷滴鼻剂的体外抑菌效果.结果:浓度为50％、25％、12.5％的十三味辛夷滴鼻剂对小鼠耳廓肿胀的抑制率分别为78.34％、70.46％、65.41％,对小鼠腹腔液的吸光度分别为(0.223±0.063)、(0.257±0.037)、(0.299±0.043)；对金黄色葡萄球菌、酿脓链球菌、甲型溶血性链球菌、肺炎链球菌的抑菌圈直径均超过16mm.结论:十三味辛夷滴鼻剂具有较强的抗炎作用,体外抑菌效果显著.%OBJECTIVE: To observe anti-inflammatory and in vitro antibacterial effect of Shisanwei xingyi drops. METHODS: In xylene-induced mice ear edema test and capillary permeability changed by acetic acid test, anti-inflammatory effect of Shisanwei xingyi drops was observed. In vitro antibacterial effect of Shisanwei xingyi drops was determined by cylinder plate method. RESULTS: Inhibition rates of 50%, 25%, 12.5% of Shisanwei xingyi drops to mice ear edema were 78.34% ,70.46% ,65.41%. The absorbance of the peritoneal fluid of mice were (0.223 ± 0.063), (0.257 ± 0.037), (0.299 ± 0.043); the inhibition zone diameter to Staphylococcus aureus, Streptococcus pyogenes, hemolytic streptococcus, Streptococcus pneumoniae were more than 16 mm. CONCLUSION: Shisanwei xingyi drops has a strong anti-inflammatory effect; In vitro antibacterial effect is remarkable.