肺癌术中胸腔喷洒甘露聚糖肽和5-氟尿嘧啶的临床观察

摘要

OBJECTIVE:To observe the efficacy and safety of spraying mannatide and 5-fluorouracil in anocelia during sur-gery of lung cancer based on the adjuvant chemotherapy. METHODS:Totally 114 patients with lung cancer radical surgery were randomly divided into observation group(59 cases)and control group(55 cases). There were spraying mannatide(40-80 mg)and 5-fluorouracil(500 mg)in the observation group;and nothing drugs were sprayed in control group. The patients higher than phaseⅡ were treated by adjuvant chemotherapy after surgery for continuous 2 cycles,21 d as a cycle. The clinical data was compared, including amount of bleeding and drainage,hospital stay,complications,toxicity,KPS score,body weight changes,immune func-tion,survival rate and recurrence rates between 2 groups. RESULTS:There were no significant differences among the amount of bleeding and drainage,hospital stay and complications in the 2 groups (P>0.05). The nausea,vomiting,leucopenia,the KPS score,improvement of total effective rate,and improvement rate of body mass,immune function,survival rate in 1 and 2 year (s),recurrence rate and time within 2 years in observation group were significantly better than control group,with significant dif-ferences(P<0.01 or P<0.05). CONCLUSIONS:Spraying mannatide and 5-fluorouracil can reduce the toxicity in anocelia during surgery of lung cancer based on the adjuvant chemotherapy,improve the immune function and survival rate,reduce recurrence rate and prolong the recurrence time.%目的：观察在辅助化疗基础上于肺癌术中胸腔喷洒甘露聚糖肽和5-氟尿嘧啶的疗效及安全性。方法：将行肺癌根治术的114例患者随机分为观察组（59例）和对照组（55例），观察组患者术中喷洒甘露聚糖肽（40～80 mg）和5-氟尿嘧啶（500 mg）；对照组患者未喷洒任何药物。两组Ⅱ期以上患者术后均常规行辅助化疗，21 d为1个周期，连续化疗2个周期。比较两组患者术后出血量、引流量、住院天数及并发症情况，毒副反应，KPS评分及体质量变化，免疫功能指标，生存率及复发率。结果：两组患者术后出血量、引流量、住院天数及并发症情况比较差异均无统计学意义（P＞0.05）。观察组患者恶心呕吐、白细胞减少发生情况显著优于对照组，KPS评分改善总有效率、体质量好转率均显著优于对照组，免疫功能指标显著优于对照组，1年和2年生存率显著优于对照组，2年内复发率、复发时间显著优于对照组，差异均有统计学意义（P＜0.01或P＜0.05）。结论：在辅助化疗基础上于肺癌术中胸腔喷洒甘露聚糖肽和5-氟尿嘧啶能降低患者毒副反应，改善免疫功能，提高生存率，降低复发率和推迟复发。