显脉獐牙菜的化学成分研究

摘要

OBJECTIVE:To study the chemical components of Swertia nervosa. METHODS:Silica gel column chromatogra-phy was used for purification and analysis of compounds’structure based on physicochemical properties and spectral data. RE-SULTS:Five compounds were isolated and identified in petroleum ether portion of S. nervosa,involving 1-hydroxy-3,7,8-trime-thoxyxanthone (1),1,8-dihydroxy-3,7-dimethoxyxanthone (2),1,8-dihydroxy-3,5-dimethoxyxanthone(3),1-hydroxy-3,5-dime-thoxyxanthone(4)and β-sitosterol(5). CONCLUSIONS:Compound 1,3 and 4 are isolated from S. nervosa for the first time,and the study has laid a foundation for the quality evaluation of S. nervosa.%目的：研究显脉獐牙菜的化学成分。方法：采用硅胶柱色谱进行分离纯化，根据理化性质和波谱数据分析鉴定化合物结构。结果：从显脉獐牙菜石油醚萃取部分中共分离得到5个化合物，分别鉴定为1-羟基-3，7，8-三甲氧基酮（1）、1，8-二羟基-3，7-二甲氧基酮（2）、1，8-二羟基-3，5-二甲氧基酮（3）、1-羟基-3，5-二甲氧基酮（4）、β-谷甾醇（5）。结论：化合物1、3、4为首次从显脉獐牙菜中分离得到，该研究为显脉獐牙菜的质量评价奠定了一定基础。