OBJECTIVE:To promote effective supervision of key monitoring drugs by provincial pharmaceutical quality control center,and to improve rational drug use. METHODS:The effects of No.2 district of Sichuan province pharmaceutical quality con-trol center on 3 categories of key monitoring drugs guidance and supervision,through urging medical institution in the area to estab-lish key monitoring drugs supervision system,formulating prescription review guideline for 3 categories of key monitoring drugs [TCM injection,adjunctive drug,proton pump inhibitors (PPIs)],developing baseline data survey,inspecting the application of key monitoring drug in medical instaurations on the spot and other measures,were introduced. Through collecting the reports of re-gional quality control center to the provincial quality control center,supervision system of medical institutions were analyzed statisti-cally. Key monitoring drugs of medical institutions in the area were analyzed statistically in respects of rational utilization ratio,uti-lization quantity,utilization amount,etc.,so as to evaluate supervision effects. RESULTS:Up to Apr. 2016,92.26%medical insti-tutions had been aware of the relevant requirements of the documents;84.25% had established the hospital supervision system. 3 categories of key monitoring drugs prescription(orders)comment guideline had been developed in Mar. 2016. 18 third-grade class-A general medical institutions were randomly selected;among 3 categories,irrational utilization ratio of TCM injection decreased by 12.35%(35.41% vs. 47.76%);that of adjunctive drugs decreased by 9.64%(20.95% vs. 30.59%);that of PPIs decreased by 7.44%(40.49% vs. 47.93%) in May 2016,compare to Jan. 2016. Average consumption sum of them decreased by 12.07%, 13.30%,9.49%,respectively in Apr. 2016,compared to Jan. 2016. 55.02% medical institutions had started to collect the baseline data. CONCLUSIONS:The provincial pharmaceutical quality control center has played an important role on establishing a supervi-sion system,it can promote the effective supervision by guiding and supervising the medical institutions evaluating the supervision of medical institutions and pointing out the problems.%目的：推动省级药事质量控制中心对重点监控药品的有效监管，促进合理用药。方法：介绍四川省药事质量控制中心二片区通过督促辖区医疗机构建立重点监控药品监管制度、制定3类重点监控药品处方点评指南、开展基线数据调查、现场督查医疗机构重点监控药品的实际使用情况等措施，发挥对3类重点监控药品[中药注射剂、辅助用药、质子泵抑制剂（PPIs）]使用的指导、督促作用；通过收集各分中心向省质控中心的工作报告，统计医疗机构建立监管制度的情况；通过随机抽样统计各分中心辖区医疗机构重点监控药品的合理使用率、使用量、使用金额等数据，对监管效果进行参考性评价。结果：截至2016年4月，92.26％的医疗机构知晓省卫计委的相关文件要求，84.25％已建立本院的监管制度；2016年3月已完成3类重点监控药品处方（医嘱）点评指南的制定；省内18家三级甲等综合医疗机构3类重点监控药品2016年5月不合理使用率与1月比较，中药注射剂下降12.35％（35.41％vs.47.76％）、辅助用药下降9.64％（20.95％vs.30.59％）、PPIs下降7.44％（40.49％vs.47.93％）；2016年4月平均销售金额与1月比较，分别下降12.07％、13.30％、9.49％；55.02％的医疗机构已启动基线数据资料收集工作。结论：省级药事质量控制中心在重点监控药品管理制度的建设上可发挥重要作用，可指导和督促医疗机构建立监管制度，评估分析各级医疗机构监管情况，指出存在的问题，进而促进重点监控药品有效监管。
展开▼
