不同配比头孢噻肟/舒巴坦对180株临床分离菌的体外抗菌活性

摘要

Objective: To study the in vitro antibacterial activities of cefotaxime and cefotaxime/sulbactam ( CTX/SBT ) with different proportions. Method: The minimal inhibitory concentrations ( MIC ) and the minimal bactericidal concentrations ( MBC ) were measured in 180 clinical isolates. Result: CTX/SBT with proportion of 1: 1 and 2'- 1 both displayed potent and broad - spectrum antibacterial activities against 180 clinical isolates in vitro, which were better than CTX and CTX/SBT with proportion of 4:1 and 8:1. MIC90 of CTX/SBT (1:1 and 2:1 ) against gram-negative bacteria was 0. 25-1 32 ing ·L-1 ,which was 1/4 ~ 1/8 of that of cefotaxime. Conclusion: CTX/SBT with proportion of 1: 1 and 2: 1 shows promising antibacterial activities against the major clinical isolates with better effect when compared with cefotaxime and cefotaxime/sulbactam with the other proportions.%目的:研究不同配比的头孢噻肟/舒巴坦及头孢噻肟单剂对临床分离菌体外抗菌作用.方法:采用平皿二倍稀释法测定头孢噻肟/舒巴坦对180株临床分离菌的最低抑菌浓度(MIC)、最低杀菌浓度(MBC).结果:头孢噻肟/舒巴坦(1:1,2:1)对180株临床分离菌具有广谱抗菌作用,对革兰阴性杆菌MIC90为0.25～32 mg·L-1,是头孢噻肟单剂的1/4～1/8,明显强于头孢噻肟单方使用效果,同时也强于头孢噻肟/舒巴坦(4:1,8:1).结论:1:1及2:1配比的头孢噻肟/舒巴坦对绝大多数临床感染细菌有很强的抗菌活性,明显优于头孢噻肟单剂和头孢噻肟/舒巴坦其他配比.