首页> 中文期刊> 《中国药业》 >云芝糖肽聚氰基丙烯酸正丁酯纳米囊的制备工艺优选

云芝糖肽聚氰基丙烯酸正丁酯纳米囊的制备工艺优选

         

摘要

Objective To investigate the current situation and development trend of narcotics use for inpatients in our hospital to provide the reference for scientific management and rational use of these drugs. Methods The statistical analysis on the application of narcotics in our hospital from 2008 to 2010 was conducted for comparison in the aspects of drug consumption sum, DDDs and defined daily cost, etc. Results The consumption of narcotics in our hospital was increased year by year, but the percentage accounting for total amount of money was declined. Leading the list in terms of consumption sum was Fentanyl Citrate Injection(0. 1 mg), which had the highest increasing trend. Conclusion The utilization of narcotics in our hospital is basically rational. The usages, total dosage and application are implemented in strict accordance with the relevant national regulations.%目的 优选界面聚合法制备云芝糖肽聚氰基丙烯酸正丁酯纳米囊的工艺.方法 以包封率为指标,通过正交试验设计优化处方.结果 制得的纳米囊外观圆整,粒径分布均匀,平均粒径为268.5 nm,包封率达83.7%.结论 云芝糖肽聚氰基丙烯酸正丁酯纳米囊制备工艺简单,优选的处方较好,所制得的微囊粒径小、分布窄,该工艺可行.

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