Objective To investigate the impact of the pharmacist intervention on prophylactic use of antibacterial drugs in several kinds of type Ⅱ incision operation. Methods The clinical data in the patients with 3 kinds of type Ⅱ incision operation(breast surgery,thy-roid surgery and hernia repair) in our hospital were collected and their prophylactic use situation of antibacterial drugs was ana-lyzed. The ways of conducting the notification in the related meetings by the leadership in charge of this work and the pharmacists go-ing to the clinical departments for implementing the monitoring were adopted for implementing the intervention. Results After the inter-vention,the choice of antibacterial agents tended to be standardized,the first - generation cephalosporins were predominant with the con-stituent ratio of 83. 58% ;followed by penicillins,the constituent ratio was 14. 93% . The use rate of single antibacterial drug after the pharmacist intervention was increased from 90. 71% to 98. 51% . The application of antibacterial drugs at 30 min to 2 h after the pharmacist intervention was increased 1. 33% to 98. 51% . The medication time of antibacterial drugs before intervention and after oper-ation was controlled within 48 h in 28 cases (12. 39% ),which was significantly lower that 27 cases(40. 30% ) after interven-tion. Conclusion The clinical pharmacists' reasonable intervention on the prophylactic antibacterial drug use in type Ⅱ incision opera-tion can make the surgical antibacterial drug use more standardized and more rational and reduce the treatment costs.%目的：探讨药师干预对Ⅱ类切口手术预防性应用抗菌药物的影响。方法收集医院3种Ⅱ类切口手术的病历资料，分析抗菌药物预防性应用情况。通过分管领导在医院相关会议上通报、药师到临床科室实施监控等方式，对其进行干预。结果经过干预，抗菌药物的选择趋于规范化，主要以第1代头孢为主(构成比为83.58%)，其次为青霉素类(构成比为14.93%)；干预后单一抗菌药物使用率由干预前的90.71%上升至98.51%；术前30 min 至2 h 应用抗菌药物由1.33%提高至98.51%。干预前及术后抗菌药物用药时间控制在48 h 内的患者有28例（12.39%），明显低于干预后的27例（40.30%）。结论临床药师对Ⅱ类切口手术抗菌药物预防性应用的合理干预，可使外科抗菌药物的使用更加规范、合理，降低治疗费用。
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