Objective To investigate the effect of atorvastatin combined with salviae miltiorrhizae and ligustrazine for treating carotid atherosclerotic plaques in the patients with cholesterolemia complicating coronary atherosclerosis heart disease. Methods Totally 126 pa-tients with cholesterolemia complicating coronary atherosclerosis heart disease were randomly divided into the observed group(63 cases) and the control group(63 cases). The control group was treated with atorvastatin,while on this basis the observed group was added with salviae miltiorrhizae and ligustrazine. The intima-media thickness(IMT),plaque area,blood lipid changes and complications were com-pared between the two groups. Results The IMT and plaque area after treatment in the observation group were(0. 74 ± 0. 04)mm and (0. 76 ± 0. 11)cm2,which were significantly lower than(0. 93 ± 0. 05)mm and(0. 98 ± 0. 13)cm2 in the control group( P ﹤ 0. 05). The levels of TC,TG,LDL-C,HDL-C,apoA,apoB and LPA after treatment in the observation group were significantly better than those in the control group( P ﹤ 0. 05). The occurrence rates of transient ischemia attack(TIA) and recurrence in the observation group were 4. 76% and 9. 52% respectively,which were significantly lower than 15. 87% and 23. 81% in the control group( P ﹤ 0. 05). Conclusion Atorvastatin combined with salviae miltiorrhizae and ligustrazine has definite effect and good safety for treating carotid atherosclerotic plaques in the patients with acute ischemic stroke and is worthy of clinical promotion.%目的：探讨阿托伐他汀联合丹参川芎嗪治疗高胆固醇血症并冠状动脉粥样硬化性心脏病（简称冠心病）对颈动脉粥样硬化斑块的影响。方法将126例患者随机分成观察组和对照组，各63例。对照组患者给予阿托伐他汀治疗，观察组患者在此基础上加用丹参川芎嗪联合治疗。比较两组患者内-中膜厚度、斑块面积、血脂变化及并发症情况。结果治疗后观察组患者的内-中膜厚度与斑块面积分别为（0.74±0.04）mm和（0.76±0.11）cm2，显著小于对照组的（0.93±0.05）mm和（0.98±0.13）cm2（ P﹤0.05）。治疗后观察组患者血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A（apoA）、载脂蛋白B （apoB）与脂蛋白 A（LPA）的体内水平均显著优于对照组（ P﹤0.05）。观察组患者短暂性脑缺血发作（TIA）与复发的发生率分别为4.76%和9.52%，均显著低于对照组的15.87%和23.81%（ P﹤0.05）。结论阿托伐他汀联合丹参川芎嗪治疗高胆固醇血症并冠心病患者颈动脉粥样硬化斑块疗效确切，安全性好，值得临床推广。
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