醒脾养儿颗粒辅助治疗小儿肺炎继发性腹泻的效果观察

摘要

目的：醒脾养儿颗粒辅助治疗小儿肺炎继发性腹泻的临床效果及安全性观察。方法选取2010年3月~2014年9月本院收治的160例肺炎继发性腹泻患儿，将其按照随机数字表法研究组和对照组，各80例。两组患儿均给予肺炎继发性腹泻的常规治疗措施，同时对照组给予口服思密达，研究组加服醒脾养儿颗粒。治疗1个疗程后，对两组患儿治疗效果、患儿症状体征改善情况及血清胃泌素(GAS)、胃动素(MOT)、生长抑素(SS)水平进行比较。结果经治疗1个疗程后，研究组的治疗总有效率达到91.25%，显著高于对照组的80.00%，差异有统计学意义(P<0.05)；在治疗期间，研究组腹泻、发热、呕吐持续时间分别为(36.3±9.6)、(40.6±6.9)、(35.5±7.4)h，对照组分别为(48.0±11.2)、(46.1±8.2)、(42.5±11.7)h，两组差异有统计学意义(P<0.05)；与同组治疗前比较，两组患儿经治疗后的血清GAS和MOT水平明显下降，SS水平明显升高(P<0.05)；与对照组治疗后比较，研究组的GAS和MOT水平降低幅度及SS水平升高幅度更为显著，差异均有统计学意义(P<0.05)，两组患儿均未见明显药物不良反应。结论醒脾养儿颗粒辅助治疗小儿肺炎继发性腹泻的效果显著，可迅速缓解患儿腹泻症状，缩短肺炎治疗时间，同时醒脾养儿颗粒对患儿血清GAS、MOT、SS水平具有明显的调节作用，值得临床推广应用。%Objective To observe the clinical effect and safety of Xingpi yanger granule as an adjuvant therapy in children with pneumonia secondary diarrhea. Methods 160 patients with pneumonia secondary diarrhea admitted into our hospital from March 2010 to September 2014 were selected and evenly divided into research group and control group by random number table.Routine treatment of secondary diarrhea of pneumonia was provided in two groups.At the same time,oral administration of smecta in the control group was added,while in research group,Xingpi yanger granule was added.After 1 course of treatment,the therapeutic effect,improvement of symptoms and signs,levels of serum gastrin (GAS),motilin(MOT)and somatostatin(SS)in the two groups was compared. Results After 1 course of treatment,the to-tal effective rate in the research group was 91.25%,which was significantly higher than 80.00% in the control group, with a statistical difference(P<0.05).During the treatment period,duration of diarrhea, fever, and vomiting in the research group was (36.3±9.6) h,(40.6±6.9) h and (35.5±7.4) h,while in the control group was (48.0±11.2) h,(46.1±8.2) h and (42.5±11.7) h in turn,the difference was significant (P<0.05).Compared with the group before treatment,levels of serum GAS and MOT after therapy in the two groups was evidently decreased,and the value of SS was greatly increased (P<0.05).Compared with the control group after treatment, the decrease range of serum GAS and MOT,and increase range of SS after treatment in the research group was more obvious with statistical differences (P<0.05).There was no obvious adverse drug reaction in two groups. Conclusion Xingpi yanger granule as an adjuvant therapy on treating pediatric pneumonia secondary diarrhea obtains a remarkable effect by quickly alleviating diarrhea and shortening treatment time of pneumonia.Meanwhile,Xingpi yanger granule plays obvious regulating roles in the levels of GAS,MOT and SS.which is worthy of clinical promotion.