Objective To investigate application on three different anesthesia scheme in the breath tube carotid stenting in experimental dogs. Methods 9 experimental dogs were randomly divided into three groups,group A (n=3):the dogs were anesthesia through intraperitoneal injection with Diazepam Diluents (10-15 mg/kg);group B (n=3):the trachea of dogs were topically anesthesia through slowly pushing 2% Lidocaine Hydrochloride Injection (2-3 ml) with 4F VER catheter after anesthesia with Diazepam Diluents;group C (n=3):the dogs were took the aerosol inhalation with the mix-ture of anesthesia (Ambroxol Hydrochloride 30 mg+2% Lidocaine Hydrochloride 5 ml+ Dexamethasone 5 mg+Normal saline 10 ml) for 15 minutes after anesthesia with Diazepam Diluents.All tracheal stent were implanted for experimental dogs after anesthesia.The blood oxygen saturation and the exposure time were recorded by electrocardiogram monitoring. Position of the stent was evaluated by DSA-3D. Results A total of 9 tracheal stents were implanted, the procedure of tracheal stent implantation in 3 cases was difficult in group A, and was repeated for 9 times,finally, 1 dog died after stent displacement within 24 h;3 stents of group B were relatively difficultly implanted in tracheal,stent was released in upper position in 1 case after operating for 5 times;tra-cheal stents implantation in 3 cases were success of disposable in group C, and the stents were in place well.Blood oxygen saturation during operation de-creased more obviously in preoperative in group A with statistically significant difference [(73.50±16.12)%v s (98.83±1.17)%,P<0.05],and the the experimental dogs were restless severely;blood oxygen saturation during operation decreased in preoperative in group B without statistical-ly significant difference [(92.67±3.32)%v s (98.83±1.17)%,P>0.05], but the restlessness of the experimental dogs were lower than group A;blood oxygen saturation during operation obviously was normal with preoperative in group C [(94.67±2.66)% v s (99.17±0.75)%,P>0.05], and there was no obvious restless for the experimental dogs.The exposure time in group A,B,C was (27.00±5.02),(12.50±1.87),(7.50±1.04) min, respectively,comparative difference between three groups was statistically significant (P<0.05), and group A had the longest exposure time,group C had the shortest expo-sure time. Conclusion The experimental dogs oral tracheal stent placement has strong feasibility and repeatability, the adverse reactions are minimum after Diazepam dilution is used for intraperitoneal injection of anesthesia combined with inhalation anesthetic mixture in the process of tracheal stent implantation, which is helpful to improve the success rate of surgery and to reduce intraoperative exposure time.%目的探讨实验犬经口气管支架置入术中3种不同麻醉方案的应用。方法9只实验犬随机分为3组，A组(n=3)院单纯采用地西泮稀释液(10~15 mg/kg)腹腔注射麻醉；B组(n=3)院地西泮稀释液麻醉实验犬后，经口置入4F单弯导管于犬气管壁表面，由上至下旋转状态中缓慢推注2%盐酸利多卡因2~3 ml局部麻醉；C组(n=3)院地西泮稀释液麻醉后面罩雾化吸入盐酸氨溴索30 mg+2%盐酸利多卡因5 ml+地塞米松5 mg+生理盐水10 ml混合液15 min。各组麻醉完成后行气管支架置入，采用心电监护仪监测各组实验犬血氧饱和度，并记录实验曝光时间，通过DSA-3D评估支架释放位置。结果共置入气管支架9枚，A组3例支架置入过程困难，反复操作9次，其中1例支架下移并导致实验犬术后24 h内死亡；B组3例支架置入较为困难，共操作5次，其中1例支架释放位置偏上；C组3例支架置入均一次性成功，且支架在位良好。A组术中血氧饱和度较术前明显下降，差异有统计学意义[(73.50±16.12)%v s (98.83±1.17)%，P<0.05]，实验犬严重躁动；B组术中血氧饱和度较术前有所下降，但差异无统计学意义[(92.67±3.32)% vs(98.83±1.17)%，P>0.05]，实验犬躁动减少；C组术中血氧饱和度较术前基本正常[(94.67±2.66)% vs(99.17±0.75)%，P>0.05]，实验犬无明显躁动。 A、B、C组曝光时间分别为(27.00±5.02)、(12.50±1.87)、(7.50±1.04)min，三组间比较差异有统计学意义(P<0.05)，其中A组曝光时间最长，C组曝光时间最短。结论实验犬经口放置气管支架具有较强的可行性和可重复性，地西泮稀释液腹腔注射麻醉结合雾化吸入麻醉混合剂在气管支架置入过程中反应最小，有助于提高手术成功率，减少术中曝光时间。
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