地榆升白片联合粒细胞集落刺激因子治疗肿瘤化疗后白细胞减少症的临床效果

摘要

目的：探讨地榆升白片联合粒细胞集落刺激因子(G-CSF)治疗恶性肿瘤化疗后白细胞(WBC)减少症的临床效果。方法选取本院2011年2月~2013年2月的122例恶性肿瘤化疗后WBC减少(WBC计数<3.9×109/L)的患者，随机分为联合组和单药组，各61例。单药组注射G-CSF，联合组口服地榆升白片+注射G-CSF。观察两组应用G-CSF天数、治疗中WBC计数最低值、化疗后感染发生率、应用升白药物的不良反应发生率。结果联合组应用G-CSF的天数为(3.54±1.23)d，低于单药组的(5.32±1.02)d；联合组的WBC计数最低值为(1.67±1.23)×109/L，高于单药组的(0.55±1.42)×109/L；联合组的感染发生率为3.28%，明显低于单药组的13.11%；两组差异有统计学意义(P<0.05)。联合组和单药组的不良反应发生率分别为9.84%和13.11%，差异无统计学意义(P>0.05)。结论地榆升白片联合G-CSF治疗恶性肿瘤化疗后WBC减少症具有时程短、疗效高、安全性好的特点，值得临床推广应用。%Objective To observe the effect of Diyushengbai tablets combined with granulocyte colony-stimulating fac-tor (G-CSF) in the treatment of leukopenia after malignant tumor chemotherapy. Methods 122 patients with leukopenia (white blood cell count<3.9í109/L) after malignant tumor chemotherapy from February 2011 to February 2013 in our hospital were evenly divided into combination group and single drug group.In the single drug group,only G-CSF was injected,while in the combination group,oral administration of Diyushengbai tablets and injection of G-CSF were ap-plied.Number of days of G-CSF,minimum value of white blood cell decreasing,incidence of infection,and incidence of adverse reaction after treatment were observed in two groups. Results In the combination group,G-CSF was used for (3.54±1.23) days,lower than (5.32±1.02) days in the single drug group.The minimum value of white blood cell count in the combination group was (1.67±1.23)í109/L,much higher than that in the single drug group,which was (0.55±1.42)í109/L.The incidence of infection in the combination group was 3.28%,lower than 13.11% in the single drug group.Two groups mentioned above all displayed statistical differences (P<0.05).There was no statistical difference (P>0.05) in in-cidence of adverse reaction in the combination group (9.84%) and the single drug group (13.11%). Conclusion Diyushengbai tablets combined with injection of G-CSF in the treatment of leukopenia after malignant tumor chemotherapy has advantages of short course of treatment,high curative effect,and good safety,it is worthy of populariza-tion and application.