老年慢性阻塞性肺疾病患者并发冠心病的相关因素分析

摘要

Objective To study the related factor in elderly patients with chronic obstructive pulmonary disease com-plicated with coronary heart disease. Methods The clinical data of 40 patients with chronic obstructive pulmonary dis-ease (pure group) and 40 patients with chronic obstructive pulmonary disease complicated with coronary heart disease (combined group) in our hospital from January 2011 to April 2012 were retrospectively analyzed,40 cases of healthy subjects were selected as control group at the same time,characteristics of clinical data were analyzed,the related factors of elderly patients with chronic obstructive pulmonary disease complicated with coronary heart disease were discussed. Results Compared with control group,platelet,CRP and FEV1%,the number of white blood cell,neutrophil and fibrinogen in combined group had significant difference(P<0.05 or P<0.01);Compared with control group,the number of white blood cell,fibrinogen and CRP and FEV1% in pure group had significant difference (P<0.05 or P<0.01);Compared with pure group,the number of white blood cell,neutrophils,fibrinogen,platelets,CRP and FEV1%in combined group had significant difference(P<0.05 or P<0.01).The number of white blood cell,platelet,fibrinogen,CRP level were the factors for affecting FEV1% of patients in combined group. Conclusion The airflow obstruction is a risk factor for coronary heart disease, here is a close relationship between systemic inflammation and coronary heart disease,it should be strengthened the relevant heart function surveillance in patients with chronic obstructive pulmonary disease in clinic,and pay close atten-tion to related parameters of systemic inflammation for facilitating timely treatment,in order to reduce the fatality rate of cardiovascular disease.%目的：探讨老年慢性阻塞性肺疾病患者并发冠心病的相关因素。方法回顾性分析2011年1月~2012年4月本院收治的40例慢性阻塞性肺疾病患者(单纯组)和40例慢性阻塞性肺疾病合并冠心病患者(合并组)的临床资料，同时选取40例健康者作为对照组，分析其临床资料特征，探讨影响老年慢性阻塞性肺疾病患者并发冠心病的相关因素。结果合并组与对照组比较，血小板、CRP、FEV1%、白细胞、中性粒细胞、纤维蛋白原差异有统计学意义(P<0.05或P<0.01)；单纯组与对照组比较，白细胞、纤维蛋白原、CRP及FEV1%差异有统计学意义(P<0.05或P<0.01)；合并组与单纯组比较，白细胞、中性粒细胞、纤维蛋白原、血小板、CRP及FEV1%差异有统计学意义(P<0.05或P<0.01)。白细胞、血小板、纤维蛋白原、CRP水平是影响合并组患者FEV1%的因素。结论气流受限是冠心病的危险因素，全身炎症与冠心病有密切关系，临床上应加强对慢性阻塞性肺疾病患者相关心功能的监测，密切关注全身炎症相关指标，便于及时治疗，以降低心血管疾病的致死率。