QIMT技术在正常人颈动脉冷加压实验中的应用价值

摘要

Objective To evaluate the feasibility of quality intima-media thickness (QIMT) in assessing function of common carotid artery (CCA) though cold pressure test(CPT). Methods Thirty healthy subjects[mean age(24.68±1.73) years old]were underwent 2D and QIMT examination under the normal quiescent and CPT condition respectively. The diastolic and systolic diameters of right-CCA were measured respectively. Corresponding the changed range and rate were calculated. After a week,under the same condition, 10 subjects who were chosen randomly were examination again to accept reproducibility test. Results The maximal and minimal diameters,changed range and rate of diameters were wider when subjects suffered CPT and measured by QIMT(P < 0.05). There was no significant difference of diameters between CPT and quiescent condition which measured by 2D. The maximal diameters measured by QIMT were well concordance [in group: r=0.92, P < 0.0001 :mean difference(0.027±0.012)mm]. Conclusion The function of CCA would be evaluated by QIMT.%目的 应用超声射频信号血管内中膜分析技术(Quality Intima-Media Thickness,QIMT)观察正常人冷加压实验前后颈总动脉内径的变化,并判断此方法评价颈总动脉功能的可行性和准确性.方法 正常健康志愿者30例,年龄(24.68±1.73)岁.应用QIMT技术和常规二维超声分别观察记录静息状态下、冷加压负荷实验后的右侧颈总动脉,测量其收缩末期和舒张末期内径,并计算内径变化范围、百分变化率.随机选取10例1周后行重复试验.结果 QIMT技术测量正常人右侧颈总动脉最大内径、最小内径、内径变化幅度及内径百分变化率在冷加压后均增宽(P<0.05).百分变化率与最大血流速度间呈线性相关;二维法,冷加压实验前后颈总动脉内径变化不明显,差异无显著性.QIMT技术重复测量最大内径组内比较均具有高度一致性.组内r=0.92,P<0.0001,平均差异(0.027±0.012)mm.结论 QIMT技术可准确测量冷加压前后颈总动脉内径变化,以及检测颈总动脉功能.