目的 研究153钐-乙二胺四甲撑膦酸(153Sm-EDTMP)治疗肺癌、乳腺癌及前列腺癌骨转移所致骨痛的疗效.方法静脉注射153Sm-EDTMP,给药剂量18.5-37.0 MBq/kg(0.5～1.0 mCi/kg)体重,每隔1～2个月注射1次.结果 153Sm-EDTMP治疗肺癌、乳腺癌及前列腺癌骨转移所致骨痛的总有效率分别为68.5%、89.3%及100%,且乳腺癌和前列腺癌的疗效与肺癌相比有统计学意义(P<0.05),81.5%患者白细胞或血小板计数一过性减少.结论 放射性核素治疗以成骨为主的骨转移灶,止痛效果明显,方法简便,不良反应小.%Objective To observe the effect of 153Sm-EDTMP for treating bone metastases of lung cancer, breast cancer and prostate cancer . Methods A hundred and sixty-six patients with bone metastases were intravenously given 153Sm-EDTMP, 18.5～37 MBq/kg (0.5～1.0mCi/kg) body weight, once a month or every 2 months. Results The effective rate of bonepain palliation of 153Sm-EDTMP treating bone metastases of lung cancer, breast cancer and prostate cancer were 68.5%, 89.3% and 100% respectively. Furthermore there was significant difference between lung cancer and breast cancer (P<0.05), 81.5% of patients suffered from side effect of transient leukopenia or thrombocypenie. Conclusion 153Sm-EDTMP shows effective in treating bone metastases of breast cancer and prostate cancer, with easy application, rare side effect.
展开▼
