妊娠相关血小板减少症的围产结局分析

摘要

Objectives To investigate the impact of pregnancy associated thrombocytopenia on the outcomes of pregnancy. Methods Totally 57 cases of pregnancy associated thrombocytopenia and 50 cases of normal platelet from January 2004 to Decepmber 2008 were reviewed. The outcomes of pregnancy between the two groups are compared. Results There was no significant difference regarding the rate of cesarean section, premature delivery, postpartum hemorrhage and neonatal asphyxia between the 2 groups (cesarean section 56.1% vs 40.0%, premature delivery 10.5% vs 8.0%, postpartum hemorrhage 70.0% vs 4.0%, meonatal asphyxia 1.8% vs 2. 0%, P<0.05). Conclusions Most pregnancy associated thrombocytopenia does not show adverse impact on mother and infant and no intervention is necessary. Corticosteroid, immunoglobulin and platelets transfusions in severe gestational thrombocytopenia should be applied to decrease the complications of mother and infant.%目的 探讨妊娠相关血小板减少症(PAT)对母婴的影响.方法 回顾性分析我院2004年1月至2008年12月57例妊娠相关血小板减少症孕妇(研究组)的临床资料,选择同期50例血小板计数正常孕妇为对照组,比较2组的妊娠结局.结果 研究组剖宫产、早产、产后出血、新生儿窒息的发生率与对照组差异无统计学意义(剖宫产率:56.1% vs 40.0%;早产率:10.5% vs 8.0%;产后出血率:7.0% vs 4.0%;新生儿窒息率1.8% vs 2.0%,均P>0.05).结论 妊娠相关血小板减少症多数预后良好,不需特殊处理,但要定期复查血小板计数;对于重度血小板减少患者,应酌情予以肾上腺皮质激素、丙种球蛋白或输血小板制剂等治疗,从而降低母婴并发症.