低分子肝素联合银杏达莫注射液治疗不稳定型心绞痛的临床观察

摘要

Objective To study the therapeutic effect of low-molecule heparin (LMWH) and Ginkgo-dipyidamolum injection for unstable angina (UA). Methods One hundred and seventy-five cases with UA were chosen from March 2006 to March 2010, completely randomly divided into treatment group (58 cases) and control group Ⅰ (52 cases) and control group Ⅱ (65 cases). On the basis of routine therapy, control and treatment groups for UA patients were established, and for experimental group, 58 patients were treated with both LMWH and Ginkgo-dipyidamolum injection. Results Statistically,compared with control group, the treatment of experimental group is more effective on aspects as follows: easing clinical symptoms, allaying myocardial ischemia diagnosed by electrocardiogram, and preventing composite of non-fatal stroke, myocardial infarction and cardiovascular death[82.76％ (48/58 ) vs 65.38％ (34/52) ,63.08％ (41/65) ;77.59％ (45/58) vs 55.77％ (29/52) ,53.85％ (35/65) ;18.97％ (11/58)vs36.54％(19/52),35.38％(23/65),P＜0. 05,P＜0.01]. Conclusion LMWH and Ginkgo-dipyidamolum injection are more effective than that of either LMWH or Ginkgo-dipyidamolum injection on abirritating myocardial blooding and relieving clinical symptom.%目的 探讨低分子肝素( LMWH)联合银杏达莫注射液治疗不稳定型心绞痛的疗效。方法 选择2006年3月至2010年3月不稳定型心绞痛患者175例，完全随机分为治疗组（58例）、对照Ⅰ组（52例）和对照Ⅱ组（65例）。在常规治疗的基础上，治疗组应用LMWH联合银杏达莫注射液治疗，对照Ⅰ组应用LMWH治疗，对照Ⅱ组应用银杏达莫注射液治疗，疗程均为2周。比较3组临床症状改善、心电图缺血改善及复合终点事件发生情况。结果 治疗后治疗组临床症状改善总有效率、心电图缺血改善总有效率、复合终点事件发生率方面明显优于对照Ⅰ组和对照Ⅱ组[分别为82.76％( 48/58)比65.38％ (34/52)、63.08％ (41/65),77.59％ (45/58)比55.77％ (29/52)、53.85％(35/65),18.97％(11/58)比36.54％( 19/52)、35.38％(23/65)]，差异有统计学意义（P＜0.05或P＜0.01）。结论 LMWH联合银杏达莫注射液可以明显改善不稳定型心绞痛患者心肌供血，缓解临床症状，疗效明显优于单用LMWH或银杏达莫注射液。