Objective To explore the clinical value of low-molecular-weight heparins calcium injection combined with puerarin in treatment of chronic pulmonary heart disease with acute exacerbation by echocardiography. Methods Sixty patients with pulmonary heart disease were randomly divided into experimental and control groups. The control group using the traditional therapy and the experimental group use low-molecular-weight heparins calcium injection combined with puerarin based on the control group. Right ventricular function before and after treatment was evaluated using color Doppler echocardiography. Results Right ventricular ejection fraction was increased by application of low-molecular-weight heparins calcium injection combined with puerarin[(25.0 ± 1.6) %vs (40.0 ± 2.3) %]. Acceleration time (AT) of pulmonary artery extend [(0.11 ± 0.01) s vs (0. 14 ± 0.01) s],and the ratio of the time before the right ventricular ejection (RPEP) and ejection time (RVET) decreased[(0.65 ±0. 053) vs (0.30 ± 0. 039)]. The total effective rate of experimental group was 93.3 % (28/30), and control group was 73.3 % (22/30). It had significantly different (P ＜ 0.05). Conclusion Low-molecular-weight heparins calcium injection combined with puerarin can reduce pulmonary arterial pressure of pulmonary heart disease, and the right ventricular function recovers significantly.%目的 应用超声心动图评价葛根素注射液加低分子肝素钙治疗慢性肺源性心脏病(肺心病)急性发作期患者的疗效.方法 将60例肺心病患者完全随机分成研究组(30例)及对照组(30例).对照组采用传统的综合疗法,研究组在对照组的基础上加用葛根素注射液400 mg静脉滴注、1 次/d和低分子肝素钙0.4 ml皮下注射、2次/d,疗程为10 d.治疗前、后使用彩色多普勒超声心动图评价2组患者的右心功能.结果 与治疗前比较,研究组治疗后右心室射血分数增加[(25.0±1.6)%比(40.0±2.3)%,P＜0.01],肺动脉血流加速时间延长[(0.11±0.01)s比(0.14±0.01)s],右心室射血前时间与射血时间的比值降低[(0.650±0.053)比(0.300±0.039),P＜0.01].对照组治疗前后和2组治疗后心功能改变各指标差异均有统计学意义(P＜0.05和P＜0.01)研究组总有效率为93.3%(28/30),对照组总有效率为73.3%(22/30),2组总有效率比较差异有统计学意义(P＜0.05).结论 葛根素加低分子肝素钙能降低肺心病急性发作期患者肺动脉压力,对肺心病右心功能具有明显的恢复作用,疗效满意.
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