香菇多糖联合化学疗法治疗胃癌的疗效观察

摘要

目的 观察香菇多糖联合化学疗法(化疗)治疗胃癌的疗效.方法 将82例胃癌患者完全随机分为观察组(42例)和对照组(40例).观察组采用香菇多糖加化疗,对照组采用单纯化疗.测定2组患者治疗前及治疗2周后外周血T淋巴细胞亚群和自然杀伤细胞活性,治疗2周后对患者疗效、免疫功能、生活质量及不良反应进行评价.结果 治疗后观察组和对照组总有效率分别为61.9％(26/42)和40％(18/40),2组比较差异有统计学意义(P＜0.05).观察组CD3、CD4、CD4/CD8比值、NK细胞活性明显高于治疗前[分别为(59±9)％比(50±8)％,(37±6)％比(34±4)％,(1.65±0.45)比(1.24±0.25),(37±8)％比(28±6)％],CDs低于治疗前[(24±4)％比(27±4)％],差异均有统计学意义(均P＜0.05)；对照组治疗后CD4/CD8比值、自然杀伤细胞活性明显低于治疗前[分别为(1.01±0.30)比(1.26 ±0.22),(24±6)％比(28±6)％],CD3高于治疗前[(51±7)％比(49±7)％],差异均有统计学意义(均P＜0.05)；观察组与对照组治疗后CD3、CD4、CD4/CD8比值、自然杀伤细胞活性比较差异均有统计学意义(均P＜0.05).观察组卡氏行为状态评分上升患者比率为47.6％(20/42),明显高于对照组[25.0％(10/40)](P ＜0.05).观察组血小板减低、白细胞减少发生率均明显低于对照组[28.6％(12/42)比45.0％(18/40),33.3％(14/42)比50.0％(20/40)],差异均有统计学意义(均P＜0.05).结论 香菇多糖联合化疗治疗胃癌的疗效优于单纯化疗,可提高患者免疫功能及临床疗效.%Objective To observe the immunologic function and effect of lentinan combined with chemotherapy in treatment of gastric carcinoma.Methods Eighty-two cases of gastric carcinoma were randomly divided into observation group(42 cases)and control group(40 cases).The patients in treatment group were treated with lentinan and chemotherapy,and the patients in control group were treated with chemotherapy only.The therapeutic effect,immune functions,Karnofsky performance status(KPS)score,adverse effect in two groups were observed and compared.Results The total effective rate in observation group and control group was 61.9％(26/42)and 40％(18/40),and there was significant difference(P ＜ 0.05).Compared to before treatment,in observation group,CDs reduced,and CD3,CD4,CD4/CD8,nature kill(NK)cell increased,while in control group,CD4/CDs and NK cell reduced,CD3 increased,and there were significant differences(all P ＜ 0.05).There was significant difference in CD3,CD4,CD4/CDs,NK cell activity between observation group and control group (P ＜ 0.05).The rate of KPS score increasing in observation group was higher than that in control group.The rates of blood platelet decreasing and leucopenia in observation group were lower than those in control group. Conclusions Lentinan combined with chemotherapy can enhance some immunological function and clinical effect in patients with gastric carcinoma.So lentinan is an important remedy adjuvant of chemotherapy.