长春西汀注射液治疗椎基底动脉供血不足性眩晕疗效观察

摘要

目的 观察注射用长春西汀治疗椎-基底动脉供血不足性眩晕的疗效.方法 将100例椎基底动脉供血不足性眩晕患者完全随机分为观察组和对照组,各50例.观察组患者给予5％葡萄糖或0.9％氯化钠注射液500 ml加长春西汀注射液30 mg,1次/d静脉滴注.对照组患者给予5％葡萄糖或0.9％氯化钠注射液250 ml加丹参注射液20ml,1次/d静脉滴注.疗程均为10 d.观察患者治疗前后的临床表现、治愈好转情况及左椎动脉、右椎动脉及基底动脉平均血液速度变化.结果 观察组显效44例、有效5例,总有效率98.3％,对照组显效24例、有效20例,总有效率90.0％,2组比较差异有统计学意义(P＜0.05)；观察组和对照组左椎动脉、右椎动脉及基底动脉平均血液速度与治疗前比均有不同程度提高[观察组:(26±8)m/s比(23±7) m/s,(27±7) m/s比(24±7) m/s,(26±8)m/s比(23 ±7) m/s,对照组:(27±8)m/s比(24±7)m/s,(27 ±7)m/s比(24 ±6) m/s,(27±8) m/s比(26±8)m/s] (P＜0.05),但2组治疗后左椎动脉、右椎动脉及基底动脉平均血液速度比较差异无统计学意义(P＞0.05).结论 注射用长春西汀治疗椎基底动脉供血不足性眩晕,疗效显著.%Objective To observe and assess the efficacy of intravenous vinpocetine treating vertebrobasilar insufficiency-associated vertigo.Methods One hundred patients were randomly divided into observation group and control group with 50 patients in each group.Patients in observing group were intravenous injected with 30 mg vinpocetine in 500 ml 5％ glucose or 0.9％ sodium chloride once a day for 10 days,while the control group accepted injection of 20 ml salvia in 250 ml 5％ glucose or 0.9％ sodium chloride with the same frequency in the same period.Clinical manifestations and vertebral-basilar artery blood flow changes were evaluated after treatment.Results The treatment was markedly effective in 44 cases,effective in 5 cases and 1 ineffetive case in observation group; the total effective rate was 98.3％.In the control group,there were 24 markedly effective,20 effective and 6 ineffetive cases.The total effective rate was 90.0％.The total effective rate was statistically different between the two groups.The left and right vertebral artery average blood speed was improved after treatment in both groups (P ＜ 0.05).Conclusion Intravenous injection of vinpocetine as a treatment of vertebrobasilar insufficiency-associated vertigo has significant effects.