北京城区长期服用非甾体消炎药患者幽门螺杆菌感染现状及影响因素分析

摘要

目的 了解北京城区长期服用非甾体消炎药(NSAID)患者幽门螺杆菌(Hp)感染现状,分析Hp感染的影响因素.方法 对190例北京城区长期服用NSAID患者行13C尿素呼气试验检查,统计Hp感染的比例,记录入选者的年龄、性别、吸烟史、饮酒史、文化程度、在职情况、胃炎及消化性溃疡家族史、饮食习惯资料,分析其与Hp感染的关系.结果 190例患者中,Hp阳性102例,占53.7％,阴性88例,占46.3％.不同年龄、在职情况、胃炎及消化性溃疡家族史和饮食习惯的患者Hp感染比例差异有统计学意义[＜40岁:60.0％(30/50),40～65岁:59.1％ (52/88),＞65岁:38.5％ (20/52);在职:80.0％ (80/100),不在职:24.4％ (22/90);有胃炎及消化性溃疡家族史:86.0％(74/86),无胃炎及消化性溃疡家族史:27.0％ (28/104);饮食规律:25.5％ (28/110),饮食不规律:92.5％ (74/80)] (P ＜0.05).结论 北京城区长期服用NSAID患者Hp感染与年龄、在职情况、胃炎及消化性溃疡家族史及饮食习惯明显相关.%Objective To analyze the status and influence factors of helicobacter pylori (Hp) infection in patients taking non-steroidal antiinflammatory drugs (NSAID) in Beijing.Methods One hundred and ninety outpatients with long term usage of NSAID in Beijing were enrolled and underwent 13C-urea breath test (13 C-UBT).The proportion of Hp infection was calculated; the correlations of age,sex,smoking history,drinking history,education degree,working condition,family history of gastritis and peptic ulcer,dietary habits with Hp infection were analyzed.Results Among these 190 patients,there were 102 Hp positive patients (53.7％) and 88 Hp negative patients (46.3％).The infection rate of Hp was significantly different among patients with different ages,working conditions,family history of gastritis and peptic ulcer disease,dietary habits [＜ 40 years old:60.0％ (30/50),40-65 years old:59.1％ (52/88),＞65 years old:38.5％ (20/52) ; working:80.0％ (80/100),not working:24.4％ (22/90) ; positive family history:86.0％ (74/86),negative family history:27.0％ (28/104); regular diet:25.5％ (28/110),irregular diet:92.5％ (74/80)] (P ＜ 0.05).Conclusion The Hp infection in patients taking NSAID drugs for long time in Beijing is significantly related to age,working conditions,family history of gastritis and peptic ulcer and diet habits.