Objective To explore the clinical effect of arthroscopic treatment assisted by intraarticular injecting different doses of glass sodium treating knee osteoarthritis.Methods A total of 93 patients with knee osteoarthritis from May 2013 to May 2014 were enrolled and underwent arthroscopic treatment assisted by intraarticular injection of glass sodium.The patients were randomly divided into low dose group (20 mg glass sodium injection),median dose group (25 mg glass sodium injection) and high dose group (30 mg glass sodium injection).One week and 3 months after treatment,the outcomes were evaluated and compared.Results The Lequence and Lysholm score before treatment showed no statistical differences among three groups (P ＞ 0.05).Compared with that before treatment,the Lequence score in the three groups 1 week and 3 months after treatment were all reduced significantly [low dose group:(5.89 ± 1.34),(5.24 ± 0.28) scores vs (10.23 ± 2.58) scores,median dose group:(5.19 ± 1.15),(3.93 ± 0.87) scores vs (10.28 ± 2.49) scores,high dose group:(5.67 ± 1.23),(4.96 ±0.14) scores vs (10.21 ±2.36) scores];the Lysholm score in the three groups were all increased[low dose group:(56.3 ± 15.8),(74.7 ± 15.4) scores vs (14.9 ± 2.7) scores,median dose group:(71.9 ± 15.4),(87.1 ± 14.5) scores vs (14.3 ±2.2) scores,high dose group:(58.7 ± 15.4),(81.2 ± 15.1) scores vs (14.4 ± 2.6) scores] (all P ＜ 0.05).The Lequence score 3 months after treatment and the Lysholm score 1 week and 3 months after treatment in median dose group were more improved compared with those in other two groups (all P ＜ 0.05).Three months after treatment,the total efficacy rate in median dose group was significantly higher compared with that in low dose and high dose group [96.8％ (30/31) vs 80.6％ (25/31),83.9％ (26/31)] (P ＜ 0.05).Conclusion Arthroscopic treatment assisted by intraarticular injection with 25 mg glass sodium is more effective in knee osteoarthritis compared with that with lower and higher doses.%目的 研究不同剂量玻璃酸钠关节腔内注射辅助关节镜下关节清理术治疗膝骨关节炎患者的临床效果.方法 连续选取2013年5月至2014年5月湖北省丹江口市第一医院收治的膝骨关节炎患者共93例,完全随机分为低剂量组、中剂量组、高剂量组,每组31例.低剂量组给予20 mg玻璃酸钠注射液关节腔内注射,中剂量组给予25 mg玻璃酸钠注射液关节腔内注射,高剂量组给予30 mg玻璃酸钠注射液关节腔内注射.对3组患者实施关节镜下关节清理术治疗.结果 治疗l周和3个月后3组患者的Lequence评分明显低于治疗前[低剂量组:(5.89±1.34)、(5.24 ±0.28)分比(10.23±2.58)分,中剂量组:(5.19±1.15)、(3.93±0.87)分比(10.28±2.49)分,高剂量组:(5.67±1.23)、(4.96±0.14)分比(10.21 ±2.36)分],Lysholm评分明显高于治疗前[低剂量组:(56.3±15.8)、(74.7±15.4)分比(14.9±2.7)分,中剂量组:(71.9±15.4)、(87.1±14.5)分比(14.3±2.2)分,高剂量组:(58.7±15.4)、(81.2±15.1)分比(14.4±2.6)分](P＜0.05);其中治疗3个月后中剂量组的Lequence评分明显低于低、高剂量组,治疗1周和3个月后Lysholm评分明显高于低、高剂量组;治疗3个月后中剂量组总有效率明显高于低、高剂量组,差异有统计学意义[96.8％ (30/31)比80.6％ (25/31)、83.9％ (26/31)] (P ＜0.05).结论 中等剂量的玻璃酸钠注射液关节腔内注射辅助关节镜下关节清理术治疗膝骨关节炎的临床疗效优于低剂量和较高剂量.
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