The development of cancer stem cell theory greatly promotes understanding of tumorigenesis.In addition to tumorigenesis, cancer stem cell also contributes to drug-resistant, recurrent and metastasis of cancer, which are all closely related with self-renewal.Self-renewal is the foundation of infinite proliferation and differentiation, and targeting to self-renewal of cancer stem cell may provide a promising strategy for treatment of cancer.%肿瘤干细胞理论的提出大大促进了人类对肿瘤发生发展的认知.除了参与肿瘤的发生,肿瘤干细胞还与肿瘤耐药、复发和引起侵袭转移密切相关.而其拥有这些生物学特性的一个重要因素是具有自我更新能力,自我更新能力是无限增殖与保持分化潜能的基础.靶向肿瘤干细胞的自我更新有望为肿瘤的治疗提出新的有效策略.
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