目的 观察中药白芍七物颗粒口服联合药物保留灌肠治疗大肠湿热型溃疡性结肠炎的临床效果.方法 选取2015年3月至2016年9月湖南中医药大学第二附属医院门诊及住院大肠湿热型溃疡性结肠炎患者共160例,按照随机数字表法分为观察组和对照组,每组80例.对照组采用口服柳氮磺嘧啶肠溶片治疗;观察组采用口服白芍七物颗粒联合药物保留灌肠(庆大霉素+地塞米松)治疗,2组疗程均为4周.对比2组患者症状消失时间、结肠镜下炎症缓解情况及临床综合疗效.结果 观察组腹泻、腹痛、黏液脓血便症状消失时间均明显短于对照组[(5.0±0.8)d比(9.0±0.8)d、(3.4±0.7)d比(5.5±0.8)d、(4.1±1.1)d比(6.3±0.8)d](均P ＜0.05).观察组炎症缓解总有效率明显高于对照组[97.5％ (78/80)比71.2％ (57/80)](P＜0.05).观察组临床总有效率明显高于对照组[97.5％(78/80)比75.0％ (60/80)] (P＜0.05).结论 白芍七物颗粒内服结合药物保留灌肠治疗大肠湿热型溃疡性结肠炎效果明显.%Objective To observe the clinical effect of Baishaoqiwu granules combined with drug retention enema on intestinal damp-heat type ulcerative colitis.Methods Totally 160 patients with intestinal damp-heat type ulcerative colitis admitted in the Second Affiliated Hospital of Hunan University of Chinese Medicine from March 2015 to September 2016 were randomly divided into observation group and control group,with 80 cases in each group.The control group took salazosulfadimidine enteric-coated tablets;the observation group took Baishaoqiwu granules and had drug retention enema (gentamicin + dexamethasone);both groups were treated for 4 weeks.Symptom disappear ance time,inflammation remission under colonoscope and clinical curative effect were analyzed.Results Diarrhea,abdominal pain and mucopurulent bloody stool disappear ance time in observation group were significantly shorter than those in control group [(5.0 ± 0.8) d vs (9.0 ± 0.8) d,(3.4 ± 0.7) d vs (5.5 ± 0.8) d,(4.1 ± 1.1) d vs (6.3 ± 0.8) d] (P ＜ 0.05).The effective rate of inflammation remission in observation group was significantly higher than that in control group[97.5％ (78/80) vs 71.2％ (57/80)] (P ＜0.05).The total clinical effective rate in observation group was significantly higher than that in control group [97.5 ％ (78/80) vs 75.0％ (60/80)] (P ＜ 0.05).Conclusion Baishaoqiwu granules combined with drug retention enema is effective in treatment of intestinal damp-heat type ulcerative colitis.
展开▼
