西安市三级综合医院质子泵抑制剂应用情况

摘要

Objective To analyze the application of proton pump inhibitors (PPIs) in 11 three-level general hospitals in Xi'an from 2013 to 2015.Methods Prescriptions of PPIs from January 2013 to December 2015 were retrospectively analyzed at 11 three-level general hospitals in Xi'an.The consumption amount,annual growth rate of consumption amount,frequency and daily cost of different sorts of PPIs were analyzed.Results The consumption of PPIs increased from 2013 to 2015;consumption amounts of oral dosage forms and injections accounted for 19.6％ and 80.4％;the compound annual growth rates of oral dosage forms and injections were 11.6％ and 29.9％;the ratio of frequency/total frequency were 55.9％ and 44.1％,respectively.During 2013-2015,the consumption amount of lansoprazole ranked the first,but its annual growth rate decreased in 2015;the annual growth rates of pantoprazole,omeprazole and esomeprazole increased from 2013 to 2015.The consumption of PPIs accounted for 2.46％,2.54％ and 2.61％ of the total amount of drug consumption from 2013 to 2015.The DDDs of Rebella's oral agent ranked the first and the DDDs of pantoprazole for injection ranked the second.Frequencies of esomeprazole's injection and pantoprazole's oral agent increased from 2013 to 2015 and ranked the first and the second.Daily costs of most PPIs decreased from 2013 to 2015.Conclusions The application of PPIs increase from 2013 to 2015 in 11 three-level general hospitals in Xi'an.Most PPIs show a good consistency between the frequency and the daily cost.%目的 分析2013-2015年西安市11家三级综合医院质子泵抑制剂(PPIs)的应用情况.方法 回顾性分析2013年1月至2015年12月西安市11家三级综合医院住院患者应用PPIs的相关信息,包括PPIs消耗金额及其所占比例排序、消耗金额年增长率、用药频度排序、日均费用等,以及同一药品不同剂型消耗金额、用药频度、日均费用.结果 2013-2015年,PPIs口服剂型和注射剂型消耗金额占总肖耗金额的比例分别为19.6％、80.4％,消耗金额呈逐年增长趋势,复合年均增长率分别为11.6％、29.9％;其用药频度占总用药频度的比值分别为55.9％、44.1％.2013-2015年兰索拉唑消耗金额及其所占比例均排在第1位,但年增长率到2015年有所下降;而泮托拉唑、奥美拉唑和艾司奥美拉唑的年增长率不断增加.3年间PPIs总消耗金额在逐年增加,占西安市11家三级综合医院年药品总消耗金额比例分别为2.46％、2.54％和2.61％.2013-2015年间雷贝拉唑口服剂、注射用泮托拉唑用药频度较高,稳居第1、2位.注射用艾司奥美拉唑、泮托拉唑口服剂的消耗金额逐年上升;雷贝拉唑、奥美拉唑、兰索拉唑和泮托拉唑口服剂型序号比值＞1.00的情况最为突出,大多数药物日均费用逐年下降.结论 西安市11家三级综合医院住院患者PPIs的应用呈持续上升趋势,多数PPIs日均费用与用药频度同步性较好.