胰腺癌组织中转化生长因子βⅡ型受体和Smad4的表达及意义研究

摘要

Objective To explore the expression and significance of transforming growth factor β type Ⅱ recepter (TβR Ⅱ),Smad4 in pancreatic cancer.Methods Expressions of TβR Ⅱ and Smad4 in 52 pancreatic cancer samples and 18 adjacent normal pancreatic samples were detected by immunohistochemistry.Correlations among expressions of TβR Ⅱ and Smad4,pathological features of pancreatic cancer and survival time of patients were analyzed.Results Positive expression rate of TβR Ⅱ in pancreatic cancer tissue was significantly higher than that in normal pancreatic tissue [55.8％ (29/52) vs 26.9％ (14/52),x2 =-8.921,P =0.003].Positive expression rate of Smad4 in pancreatic cancer tissue was significantly lower than that in normal pancreatic tissue [48.1％ (25/52) vs 92.3 ％ (48/52),x2 =24.31,P ＜ 0.001].Expression of TβR Ⅱ was related to the TNM classification of pancreatic cancer(x2 =6.195,P =0.045).Median survival time of patients with positive Smad4 expression was significantly longer than that of patients with negative Smad4 expression (12.1 months vs 7.9 months,Log-Rank =14.622,P ＜ 0.001).Conclusion Patients with negative Smad4 expression are associated with shorter survival period and poor prognosis of pancreatic cancer;there is a correlation between Smad4 expression and TβR Ⅱ expression.%目的 探讨胰腺癌组织中转化生长因子βⅡ型受体(TβRⅡ)和Smad4的表达及临床意义.方法采用免疫组织化学方法检测52例胰腺癌及18例癌旁正常胰腺组织中TβRⅡ和Smad4的表达情况,分析TβRⅡ和Smad4的表达与胰腺癌患者临床病理特征及生存时间的关系.结果 胰腺癌组织TβRⅡ的阳性表达率明显高于正常胰腺组织[55.8％(29/52)比26.9％(14/52),x2=8.921,P=0.003];胰腺癌组织Smad4的阳性表达率明显低于正常胰腺组织[48.1％ (25/52)比92.3％ (48/52),x2=24.31,P＜0.001].TβRⅡ的表达与胰腺癌TNM分期存在相关性(,=6.195,P=0.045).胰腺癌组织中Smad4表达阳性患者的中位生存时间明显长于表达阴性患者(12.1个月比7.9个月,Log-Rank=14.622,P＜0.001).结论 胰腺癌中Smad4表达阴性的患者生存时间更短,预后差,且与TβRⅡ的表达具有相关性.