磷霉素氨丁三醇散治疗Ⅰ度和Ⅱ度阴道前壁膨出合并泌尿系感染的临床效果观察

摘要

Objective To observe the clinical effect of fosfomycin trometamol powers on grade Ⅰ and Ⅱ anterior vaginal wall cystocele complicated with urinary infection.Methods Totally 100 female patients diagnosed of grade Ⅰ and Ⅱ anterior vaginal wall cystocele complicated with urinary infection from July 2015 to July 2017 in Beijing Tongren Hospital,Capital Medical University were enrolled.According to the degree of disease,the patients were divided into grade Ⅰ group (n =56) and grade Ⅱ group (n =44).All patients were treated with fosfomycin trometamol powers for 2 weeks.The therapeutic effect was analyzed.Results After 2 weeks of treatment,urinary infection in 40 patients were cured and 10 patients got better in grade Ⅰ group,the total effective rate was 89.3％ (50/56);32 patients were cured and 8 patients got better in grade Ⅱ group,the total effective rate was 90.9％ (40/44).There was no significant difference of the total effective rate of urinary infection between groups(P ＞0.05).After treatment,anterior vaginal wall cystocele in 38 cases were cured and 10 cases got better in grade Ⅰ group,the total effective rate was 85.7％ (48/56);10 cases were cured and 15 cases got better in grade Ⅱ group,the total effective rate was 56.8％ (25/44).The total effective rate of anterior vaginal wall cystocele in grade Ⅱ group was significantly lower than that in grade Ⅰ group (P =0.001).Conclusions Urinary infection is one of the causes of anterior vaginal wall cystocele.Fosfomycin trometamol powers are effective in treating urinary infection and anterior vaginal wall cystocele,especially for grade Ⅰ anterior vaginal wall cystocele.%目的 观察磷霉素氨丁三醇散治疗Ⅰ度和Ⅱ度阴道前壁膨出合并泌尿系感染的临床效果.方法 选取2015年7月至2017年7月于首都医科大学附属北京同仁医院确诊的Ⅰ度和Ⅱ度阴道前壁膨出合并泌尿系感染的女性患者100例,将患者根据阴道前壁膨出程度分为Ⅰ度组(56例)和Ⅱ度组(44例).2组患者均给予磷霉素氨丁三醇散口服治疗2周.比较2组泌尿系感染和阴道前壁膨出的治疗效果.结果 治疗2周后,Ⅰ度组泌尿系感染治愈40例、有效10例、无效6例,总有效率为89.3％ (50/56);Ⅱ度组泌尿系感染治愈32例、有效8例、无效4例,总有效率为90.9％ (40/44).2组泌尿系感染的治疗总有效率比较,差异无统计学意义(P＞0.05).治疗2周后,Ⅰ度组阴道前壁膨出治愈38例、有效10例、无效8例,总有效率为85.7％(48/56);Ⅱ度组阴道前壁膨出治愈10例、有效15例、无效19例,总有效率为56.8％ (25/44).Ⅱ度组阴道前壁膨出的治疗总有效率明显低于Ⅰ度组,差异有统计学意义(P=0.001).结论 泌尿系感染可能是引起或诱发加重轻度阴道前壁膨出的原因之一.磷霉素氨丁三醇散不但可以治疗泌尿系感染,而且还可以改善甚至恢复阴道前壁及膀胱的解剖位置,特别对Ⅰ度阴道前壁膨出者疗效尤为明显,其治疗时间短,治疗方法简单,效果较好.