新疆地区各民族乙型肝炎感染者血清标志物和PreS2Ag/PreS2Ab的对照研究

摘要

Objective To acquaint the relationship of serologic marker and PerS2Ag/PerS2Ab among HBV infected people from different ethnics,which contain Han,Kazak,Uigur,Mongolia and Hui people in Xinjiang. Methods Applied PreS2Ag and PreS2Ab ELISA kit,and tested PreS2Ag and PreS2Ab of 318 HBV infected cases from different ethnics in Xinjiang. Results Among 129 cases HBeAg(+)group,positive case of PreS2Ag was 119 and PreS2Ab was 10,the positive rates were 92.25%,8.40%,respectively.While among 189 cases Anti- HBe(+)group,positive case of PreS2Ag was 148 and PreS2Ab was14,the positive rates of PreS2Ag and PreS2Ab were 78.31%and7.41%,respectively. Conclusion By statistical treatment,the positive rate of PreS2Ag among HBV infected people from different ethnics in Xinjiang has significant difference between HBeAg(+)group and Anti-HBe(+)group(x2=8.583,P<0.05).In HBeAg(+) group,positive rates of PreS2Ag and PreS2Ab were different,there is no significant difference among ethnics (x2=3.84, P > 0.05).In Anti-HBe(+)group,compare Han people with Uiger and Kazak,(x2=7.88,14.43, P < 0.05);Compare positive rate of PreS2Ab between Han people and Hui people (x2=4.64,P<0.05).%目的：了解新疆地区汉、哈、维、蒙古、回族乙性肝炎病毒感染者血清标志物和与Pre2Ag、PreSAb之间的关系。方法应用乙性肝炎病毒PreS2Ag、PreS2Ab酶联免疫试剂，检测了新疆地区318例不同民族HBV感染者中的PreS2Ag、PreS2Ab。结果在新疆地区129例HBeAg（+）组中，PreS2Ag阳性119例，PreS2Ab阳性10例，阳性率分别为92.25%、8.40%；在189例Anti-HBe（+）组中，PreS2Ag阳性148例，PreS2Ab阳性14例，阳性率分别为78.31%、7.41%。结论在新疆的各民族HBV感染者HBeAg（+）和Anti-HBe（+）组中的Pre2Ag的阳性率，经统计（x2=8.583，P＜0.05）差异有统计学意义。在HBeAg（+）组中，PreS2Ag、preS2Ab的阳性率各有不同，各民族之间，经统计（x2=3.84，P＞0.05），差异无统计学意义。在Anti-HBe（+）中，汉族与哈、维族的阳性率比较（x2=7.88、14.43，P＜0.05）。汉族与回族PreS2Ab比较（x2=4.64，P＜0.05），差异有统计学意义。