IGF-1防治感音神经性耳聋及机制的研究进展

摘要

Sensorineural hearing loss is a common disease and apoptosis of cochlear cells is one of the most common causes. Insulin like growth factor-1(IGF-1) activates cell cycle and inhibits apoptosis by diverse signal transduction pathways,plays an important role in the regulation of cochlear growth, development and differentiation,and maintaining cochlear survival and recovery under cochlear cell damage. There were some progresses in the treatments of sudden deafness and drug deafness by local application of IGF-1.%感音神经性耳聋是耳鼻咽喉科常见病，耳蜗细胞凋亡是感音神经性耳聋的主要原因之一。IGF-1通过多种信号转导途径激活细胞周期和抑制细胞凋亡，从而参与耳蜗细胞正常的生长、发育和分化，以及在耳蜗细胞损伤时参与维持细胞的存活和修复。IGF-1局部应用对于治疗突发性聋、药物性聋等感音神经性聋方面的研究取得了进展。