不孕不育患者抗子宫内膜抗体、抗精子抗体与抗苗勒管激素的检测价值

摘要

目的：探讨不孕不育患者抗子宫内膜抗体（EMAb）、抗精子抗体（AsAb）与抗苗勒管激素（AMH）的检测价值。方法选取2011年5月～2014年5月我院就诊的不孕不育夫妇80对，另选择同期健康及近3年内有生育史夫妇60对作为对照组。采用酶联免疫吸附试验测定比较两组患者EMAb、AsAb和AMH的情况。结果不孕不育组血清EMAb、AsAb阳性率和AMH水平均明显高于对照组，差异有统计学意义（P＜0.05）；不孕不育患者联合检测EMAb、AsAb阳性率明显高于单独检测EMAb、AsAb，差异有统计学意义（P＜0.05）。不孕不育组精液异常患者AsAb阳性率明显高于精液正常者，差异有统计学意义（P＜0.05）。结论 AsAb、EMAb和AMH与不孕不育的发生密切相关，联合检测EMAb、AsAb在不孕不育的诊断及治疗监测方面具有重要的价值。%Objective To investigate the detective value of anti endometrial antibody(EMAb),antisperm antibody(AsAb)and anti-mullerian hormone(AMH)in patients with infertility.Methods80 couples of infertility who were treated in our hospital from May 2011 to May 2014 were selected,and 60 healthy couples with fertility history in the last 3 years were selected as the control group.EMAb,AsAb and AMH in the two groups were determined by enzyme-linked immunosorbent assay and compared. Results The positive rates of serum EMAb,AsAb and level of serum AMH in infertility group were significantly higher than those in the control group,the difference was statistically significant(P<0.05);and the positive rate of combined detection of EMAb and AsAb in patients with infertility was significantly higher than that of single EMAb or AsAb,the difference was statistically significant(P<0.05).The positive rate of AsAb in infertile group with abnormal sperm was significantly higher than that with normal sperm, and the difference was statistically significant(P<0.05).ConclusionAsAb,EMAb and AMH are closely related to the occurrence of infertility,and the combined detection of EMAb and AsAb has important value in the diagnosis and treatment of infertility.