急性白血病患者血清中白细胞介素-21的表达及其意义

摘要

Objective To integrative the clinical significance of serum interleukins-21 (IL-21) expression in patients with acute leukemia.Methods 65 patients with acute leukemia were chosen and divided into acute lymphocytic leukemia (ALL) group (31 cases) and acute myeloid leukemia (AML) group (34 cases) according to the condition of the disease. Both the groups were treated with standard chemotherapy, and the level of IL-21 were tested before and after the treatment.Results The serum level of IL-21 in ALL group and AML group was significantly higher than that in healthy group(P<0.05) and the serum level of IL-21 in ALL group was significantly higher than that in AML group(P<0.05). The female patients serum level of IL-21 in ALL group was significantly higher than that of male patients in ALL group and female patients in AML group(P<0.05). Both in ALL and in AML group the levels of WBC and peripheral blood immature cells showed significantly difference(P<0.05).Conclusion Acute leukemia can be tested by detecting serum level of IL-21 in patients, and it is helpful to distinguish between ALL and AML. It has certain clinical value and is worth of clinical promotion and further study.%目的 探讨白细胞介素-21在急性白血病患者血清中的表达情况及其意义.方法 选择符合标准的65例白血病患者,根据疾病发生情况分成急性淋巴细胞性白血病(ALL)组(31例)与急性髓性细胞白血病(AML)组(34例),测定常规化疗前后患者血清IL-21水平. 结果 ALL组与AML组血清IL-21水平均显著高于健康组(P<0.05),且ALL组显著高于AML组(P<0.05).ALL组女性患者血清IL-21值均显著性高于ALL组男性患者与AML女性患者(P<0.05).在ALL组与AML组中,IL-21R阳性患者于IL-21R阴性患者在WBC与外周血幼稚细胞水平上存在显著性差异(P<0.05).结论 通过检测患者血清中的IL-21水平能够用于辅助诊断急性白血病,同时区分ALL与AML,具有一定的临床价值,值得临床进行推广并进一步深入研究.