目的：探讨缺铁性贫血采用琥珀酸亚铁口服与蔗糖铁静脉应用效果进行比较。方法本次选取缺铁性贫血患者60例作研究对象，均为我院2010年4月～2014年4月收治，随机分为两组，琥珀酸亚铁口服组（n=30）与蔗糖铁静脉组（n=30）效果进行比较。结果静脉组总有效率为96.7%，高于口服组86.7%，但差异无统计学意义（P＞0.05）；静脉组治愈率为90.0%，显著高于口服组63.3%，差异有统计学意义（ P＜0.05）。两组治疗前Hb、SF值比较差异无统计学意义（P＞0.05），干预后均有改善，但静脉组改善幅度明显优于口服组（P＜0.05）。静脉组仅轻微头晕1例，占3.3%；口服组便秘1例，头晕2例，恶心2例，食欲不振1例，呕吐1例，总不良事件率为23.3%，差异有统计学意义（P＜0.05）。结论缺铁性贫血的患者，采用蔗糖铁静脉给药，可提高治愈率，改善临床症状，降低不良反应，具有非常积极的临床意义。%Objective To study the comparative clinical effect of oral ferrous succinate and intravenous iron sucrose in the treatment of iron deficiency anemia. Methods60 patients with iron deficiency anemia who were selected in our hospital from April 2010 to April 2014 were randomly divided into oral group treated with ferrous succinate and intravenous group treated with iron sucrose,with 30 cases in each group.Results The total effective rate was 96.7% in oral group and 86.7% in intravenous group without significant difference(P>0.05).The cure rate was significantly higher in oral group(90%)than which in intravenous group(63.3%),there were significant differences between each other(P<0.05).Hb and SF,which had no significant difference before treatment in the two groups(P>0.05),had improved by intervention and was better in intravenous group than which in oral group(P<0.05).The total rate of adverse events was 3.3% in intravenous group with 1 case of slight dizziness,and which was 23.3% in oral group with 1 case of constipation,2 cases of dizziness,2 cases of nausea,1 case of anorexia,and 1 case of vomiting,the differences was statically significant(P<0.05).Conclusion Intravenous iron sucrose in the treatment of iron deficiency anemia could improve the cure rate and the clinical symptoms,could reduce the adverse reaction,and has very positive clinical significance.
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