ObjectiveTo explore the relationship between thyroid peroxidase antibodies (TPOAb) and thyroid-stimulating hormone (TSH) in the first trimester pregnancy and the pregnancy outcome.Methods60 cases of pregnant women with pregnant week for 16weeks to 24 weeks cured in our hospital from October 2014 to October 2015 were selected as the objects. Immunoassay method was used to determine serum TSH. Electro chemiluminescence immunoassay was used to determine TPOAb. Thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase antibody (TPOAb) levels in the serum of pregnant women and TSH level of TPOAb negative and TPOAb positive pregnant women were recorded. Rate of threatened abortion, threatened premature labor, premature birth rate and other adverse pregnancy rates of TPOAb negative and TPOAb positive pregnant women were recorded.Results Among the 60 cases of pregnant women, TSH level of normal pregnant women was in 28 cases, accounting for 46.7%, and TSH level abnormal pregnant women was in 32 cases, accounting for 53.3%. There were 27 cases of TPOAb positive pregnant women, accounting for 45.0%, there were 33 cases of TPOAb native pregnant women, accounting for 55.0%. Among them, there were 22 cases (68.75%) of TPOAb positive patients with abnormal TSH level, there were 5 cases (17.86%) of TPOAb positive patients with normal TSH level, and TSH level of different patients with the incidence of TPOAb positive rate was significantly different (P<0.05). The level of TSH in serum of TPOAb positive group and negative group showed that positive group (27/60), negative group (33/60), there were only 3 cases of abnormal TSH among the 33 cases of TPOAb negative pregnant women. Therefore, the abnormal level of TSH in serum of TPOAb positive group and negative group was compared, and the difference was statistically significant (P<0.05). Incidence rate of threatened abortion, threatened premature labor, premature delivery rate, and other adverse pregnancy rates (40.7%) in the TPOAb positive group were significantly higher than those of TPOAb negative group, and the differences were statistically significant (P<0.05).ConclusionDetection of TPOAb and TSH can improve the detection rate of thyroid dysfunction. Thyroid disorder of TPOAb positive pregnant women is significantly increased. This has obvious significance to the development of the fetus and pregnant women's life and health. It is worthy to be applied widely in clinic.%目的：探究孕妇妊娠早期甲状腺过氧化物酶抗体（TPOAb）与促甲状腺激素（TSH）的关系以及妊娠结局。方法选取2014年10月～2015年10月我院接收的60例孕周为16～24周的孕妇进行研究。血清中TSH采用免疫发光分析法测定，TPOAb采用电化学发光免疫分析法测定。记录孕妇血清中的促甲状腺激素（TSH）与抗甲状腺过氧化物酶抗体（TPOAb）水平，以及TPOAb阴性、TPOAb阳性孕妇的TSH水平，记录TPOAb阴性、TPOAb阳性孕妇的先兆流产率、先兆早产率、早产率等不良妊娠发生率。结果60例孕妇中，TSH水平正常的孕妇28例，占46.7%，TSH水平异常的孕妇32例，占53.3%；TPOAb阳性孕妇有27例，占45.0%；TPOAb阴性孕妇有33例，占55.0%。其中TSH水平异常患者的TPOAb阳性有22例（68.75%）， TSH水平正常患者的TPOAb阳性有5例（17.86%），TSH水平不同患者的TPOAb阳性发生率比较，差异明显（P＜0.05）；根据TPOAb阳性组与阴性组孕妇血清中TSH水平得出，阳性组（27/60），阴性组（33/60），33例TPOAb阴性孕妇仅有3例TSH异常，因此，TPOAb阳性组与阴性组孕妇血清中TSH异常水平比较，差异具有统计学意义（P＜0.05）；TPOAb阳性组产妇的先兆流产率、先兆早产率、早产率等不良妊娠发生率（40.7%）明显高于TPOAb阴性组，差异具有统计学意义（P＜0.05）。结论 TPOAb和TSH的检测可以提高甲状腺功能紊乱的检测率，TPOAb阳性的孕妇甲状腺紊乱显著增多，对胎儿的发育以及孕妇的生命健康意义明显，值得在临床上大力应用推广。
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