目的：探讨前列地尔联合雾化吸入硝普钠治疗新生儿持续肺动脉高压的疗效。方法回顾性分析2012年5月～2015年5月我院收治的200例肺动脉高压的新生患儿临床资料，根据治疗方法不同分为两组，每组100例，所有患儿均给予头罩加压吸氧、抗凝、强心、利尿等基础治疗，观察组在此基础上给予前列地尔和雾化吸入硝普钠。观察两组患儿临床疗效，以及治疗前后的动脉血氧饱和度（SaO2）、肺动脉收缩压(PAP)、心率（HR）、血压（BP）和血氧分压（PaO2）等指标变化。结果观察组患儿总有效率为90.0%，明显高于对照组57.0%，且比较差异有统计学意义（P＜0.05）；两组治疗前PAP、SpO2、PaO2、BP、HR等指标比较差异无统计学意义（P＞0.05）；观察组治疗后PAP、SpO2、PaO2等指标与治疗前及对照组治疗后比较，差异均有统计学意义（P＜0.05）。结论前列地尔联合雾化吸入硝普钠是治疗新生儿肺动脉高压的有效方法。%ObjectiveTo investigate the curative effect of alprostadil combined with sodium nitroprusside inhalation in the treatment of neonatal persistent pulmonary hypertension. MethodsThe clinical data of 200 cases with pulmonary arterial hypertension newborn children in our hospital from May 2012 to May 2015 were retrospectively analyzed, divided in accordance with different methods in the treatment for two groups, with 100 cases in each group, all patients were given head mask pressurized oxygen, anticoagulation, strong heart, diuresis therapy, the observation group further received alprostadil and atomized inhalation of sodium nitroprusside. The clinical curative effect of two groups was observed, as well as treatment before and after arterial oxygen saturation (SaO2), pulmonary arterial systolic blood pressure (PAP), heart rate (HR), blood pressure (BP) and blood oxygen partial pressure (PaO2) and other indicators.Results The total effective rate of observation group was 57%, significantly higher than that in the control group (P>0.05), and the difference was statistically significant (P<0.05). The two groups had no significant difference (SpO2), PAP, PaO2, BP, HR, PAP, SpO2, and PaO2, and the difference was statistically significant (P<0.05). ConclusionThe alprostadil combined with sodium nitroprusside inhalation is an effective method for the treatment of neonatal pulmonary hypertension.
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