氨基末端B型脑钠肽前体、高敏C反应蛋白与脾肾阳虚型慢性心力衰竭的相关性探讨

摘要

目的:探讨氨基末端B型脑钠肽前体(NT-proBNP)、高敏C反应蛋白(hs-CRP)与脾肾阳虚型慢性心力衰竭的相关性,为脾肾阳虚型慢性心力衰竭的中医证型提供客观依据.方法:将入选的180例慢性心力衰竭患者进行中医辨证分型,分为脾肾阳虚型90例与非脾肾阳虚型90例两组,两组分别测定NT-proBNP、高敏C反应蛋白(hs-CRP)水平.结果:脾肾阳虚型慢性心力衰竭组患者的NT-proBNP、hs-CRP水平与非脾肾阳虚型组患者比较,差异均有高度统计学意义(均P<0.01).结论:NT-proBNP、hs-CRP可以作为评价脾肾阳虚型慢性心力衰竭的客观性指标,并具有临床可行性.%Objective: To investigate correlation of N-terminal portion of brain natriuretic (NT-proBNP), high-sensitive C-reactive protein (hs-CRP) and spleen-kidney yang deficiency of chronic heart failure (CHF), and to provide objective basis for spleen-kidney yang deficiency of symptoms and signs in traditional Chinese medicine. Methods: 180 patients with CHF were analyzed with symptoms and signs in traditional Chinese medicine. They were divided into spleen-kidney yang deficiency group (90 cases) and non-spleen-kidney yang deficiency group (90 cases), the levels of NT-proBNP and hs-CRP were measured. Results: The levels of NT-proBNP and hs-CRP in spleen-kidney yang deficiency group were compared with non-spleen-kidney yang deficiency group, there were significant differences between them (all P<0.01). Conclusion: NT-proBNP and hs-CRP may be objectivity indexes for patients of spleen-kidney yang deficiency with chronic heart failure, and have clinical feasibility.