Objective: To investigate the association between artery atherosclerosis and plasma asymmetric dimethylargi -nine(ADMA) concentration in type 2 diabetes patients who were new diagnosed. Methods: 60 cases of 2 diabetes patients and 40 cases of age-matched healthy controls from the third people's hospital of Qujing City from June 2008 to December 2009,were enrolled in this study. Color Doppler ultrasonography was used to determine intimamedial thickness (IMT) of carotid artery and atherosclerotic plaques, plasma ADMA levels were determined by ELISA, and fasting blood sugar, triaglyceride, cholesterol and low density lipoprotein were measured by automatic biochemistry analysis apparatus. Results: The mean IMT value (1.2±0.6) mm in type 2 diabetes patients were higher than those of controls (0.4 ±0.1) mm (P<0.01); and the arterial carotis atheromatous plaque detection rate (59.2%) in type 2 diabetes patients were also higher than those of controls (12.4%)(P<0.01); the plasma ADMA levels (16.9±7.6) μmol/L in type 2 diabetes patients were significantly higher than the controls(1.5±0.4) μmol/L (P<0.01); linear correlation analysis demonstrated carotid artery IMT correlated with blood plasma ADMA level (r=0.84, P<0.05). Conclusion: In type 2 diabetes patients, atherosclersis is related to blood plasma ADMA levels, and blood plasma ADMA may play an important role in development and progression of artery atherosclerosis.%目的:探讨新发的2型糖尿病(T2DM)患者动脉粥样硬化(AS)与血浆不对称性二甲基精氨酸(ADMA)浓度的关系.方法:收集2008年6月～2009年12月曲靖市第三人民医院内科住院新诊断并且病程在5年之内的60例T2DM患者以及与其性别、年龄匹配的健康查体40例作为对照组,采用彩色多普勒超声检测颈动脉内膜-中层厚度(IMT)及粥样硬化斑块情况,酶联免疫吸附(ELISA)法检测血浆ADMA浓度,生化分析仪检测空腹血糖(FBS)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c).结果:T2DM患者IMT值为(1.2±0.6)mm,显著厚于对照组的(0.4±0.1)mm(P<0.01);T2DM组患者动脉粥样斑块检出率为59.2%,显著高于对照组的12.4%(P<0.01);T2DM组患者血浆ADMA浓度(16.9±7.6)μmol/L,高于对照组的(1.5±0.4)μmol/L,差异有统计学意义(P<0.01);相关分析表明颈动脉IMT值与血浆ADMA成正相关(r=0.84,P<0.05).结论:T2DM患者血浆ADMA水平明显增高,ADMA在AS的发生、发展中可能起了重要作用.
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