Objective: To discuss the effectiveness of Hydrochlorothiazide (HCTZ) in the treatment of pediatric nocturnal enure -sis. Methods: 100 children who were diagnosed as nocturnal enuresis in our hospital from January 2010 to September 2010 were prospectively enrolled, with 95 cases enrolled actually. 95 cases were randomly divided into experimental group (47 cases) and control group (48 cases). HCTZ was given in the experimental group, and placebo was given in the control group. The reduction of wet nights was evaluated during the follow-up, as well as adverse effects, which were compared between the two groups. Results: All included patients had no significant adverse events. Both HCTZ and placebo were statistically effective in treating nocturnal enuresis (57.4% vs 33.3%, P=0.018), but the efficacy of HCTZ in treating children who had nocturnal enuresis reductions of more than 50% was better than placebo (35.0% vs 12.5%, P=0.018). The difference was statistically significant. Conclusion: It is safe and effective of HCTZ in treating children with nocturnal enuresis. However, its clinical value deserves further definition in future controlled trials.%目的:探讨氢氯噻嗪治疗夜尿症的有效性.方法:前瞻性纳入2010年1月～2010年9月我院夜尿症患儿100例,实际纳入病例95例,将其分为实验组(47例)和对照组(48例).实验组服用氢氯噻嗪,对照组服用安慰剂.评估夜尿症的缓解情况及药物不良反应,并比较两组间的差异.结果:所有纳入患者均对药物有较好的耐受性.氢氯噻嗪和安慰剂均能明显缓解夜尿症的发生(57.4% vs 33.3%),差异具有统计学意义(P=0.018),但氢氯噻嗪降低夜尿症频率缓解程度50%以上者较安慰剂效果更明显(48.1% vs 12.5%),差异具有统计学意义(P=0.018).结论:氢氯噻嗪能安全而有效地缓解儿童夜尿症,但是在以后的研究和临床中其临床效果仍有待于进一步证实.
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