Objective: To investigate the clinical therapeutic effect of Cinobufacini combined with Docetaxel on the advanced stomach cancer. Methods: 86 patients with advanced stomach cancer were randomly divided into observation group (43 cases) and control group (43 cases). The patients in the observation group were treated continuously with Docetaxel 120 mg +0.9% sodium chloride 250 ml dl for 3 weeks as onecycle, meanwhile continuously with Cinobufacini 20 ml + 0.9% sodium chloride 250 ml intravenous drip for 2 weeks, once a day, 2 weeks treatment and 1 week rest for 1 cycle; while the patients in the control group were treated continuously with Docetaxel 120 mg+0.9% sodium chloride 250 ml dl only for 3 weeks as one cycle, two groups were all treated with three circles. Results: There was no statistical difference in curative effect and adverse reaction between the two groups (P>0,05). However there were significant differences between the two groups in the pain relief rate (79.09% vs 32.56%) and the effective rate of increasing life quality (76.74% vs 55.81%). Conclusion: Cinobufacini combined with Docetaxel can alleviate pain distinctly and improve the life quality for the patients with advanced stomach cancer. It is a safe and effective appeasement therapeutic method.%目的:观察华蟾素注射液联合化疗对晚期胃癌的治疗效果.方法:86例晚期胃癌患者随机分为两组.观察组43例,采用多西他塞注射液(多帕菲)120 mg+0.9%氯化钠250 ml静脉滴注d1,3周重复,同时加用华蟾素注射液20 ml+0.9%氯化钠250 ml,1次/d,静脉滴注,连用2周休息1周为1个周期.对照组43例,采用多西他塞注射液120 mg+0.9%氯化钠250 ml静脉滴注d1,3周重复.两组均用3个周期.结果:两组近期疗效及不良反应差异无统计学意义(P>0.05),观察组疼痛缓解率为79.07%,提高生活质量的有效率76.74%;对照组疼痛缓解率32.56%,提高生活质量的有效率为55.81%,两组比较差异均有统计学意义(P<0.05).结论:华蟾素注射液联合多西他塞注射液治疗晚期胃癌能明显缓解疼痛,改善生活质量,是一种安全有效的姑息治疗方法.
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