血清癌抗原125和甲胎蛋白与胎盘早剥的相关性分析

摘要

Objective: To analyze the association of cancer antigen 125 (CA125) and alpha fetoprotein (AFP) levels to placental abruption. Methods: 68 patients with placental abruption from October 2003 to December 2010 were selected as case group and 50 healthy gravida as the healthy control group. The serum CA125 and AFP of two groups were detected.Results: Levels of CA125 and AFP of case group [(51.8±23.5) U/ml and (0.29±0.10) mg/L] were significantly higher than the control group [CA125 (21.4±12.4) U/ml and AFP (0.17±0.07) mg/L] (P＜0.01), placental abruption grade Ⅲ CA125 [(69.34±32.16) U/ml] and AFP (0.31±0.10) mg/L was significantly higher than grade Ⅱ CA125 (58.23±29.34) U/ml, AFP (0.24±0.09) mg/L] and grade Ⅰ [CA125(51.00±23.49) U/ml, AFP(0.20±0.06) mg/L], and difference of AFP level of grade Ⅰ and grade Ⅱ was significantly (P＜0.05). AFP serum CA125 and placental abruption were significantly positively correlated (r=0.651, P＜0.01). Conclusion: CA125 and AFP is sensitive biomarker for the early diagnosis of placental abruption,combined detection of the two can improve the diagnosis of placental abruption.%目的:探讨血清癌抗原125(cancer antigen 125,CA125)和甲胎蛋白(alpha-fetoprotein,AFP)检测在胎盘早剥中的诊断价值.方法:选择2003年11月～2010年12月收治的68例胎盘早剥患者为胎盘早剥组和100例健康孕妇为对照组,分别检测两组血清CA125和AFP.结果:CA125和AFP胎盘早剥组水平分别为(51.8±23.5)U/ml和(0.29±0.10)mg/L,明显高于健康对照组[CA125(21.4±12.4)U/m1和AFP(0.17±0.07)mg/L],差异有高度统计学意义(P＜0.01),胎盘早剥Ⅲ度CA125[(69.34±32.16)U/ml]和AFP[(0.31±0.10)mg/L]水平明显高于Ⅱ度CA125[(58.23±29.34)U/ml],AFP[(0.24±0.09)mg/L]和Ⅰ度CA[125(51.00±23.49)U/ml],AFP[(0.20±0.06)mg/L]的水平,并且AFP水平Ⅱ度和Ⅰ度比较,差异有统计学意义(P＜0.05).胎盘早剥患者血清CA125和AFP呈显著正相关(r=0.651,P＜0.01).结论:CA125和AFP是诊断胎盘早剥的敏感生物学标志物,两者联合检测可提高胎盘早剥的诊断率.