Objective: To investigate the therapeutic efficacy of using the recombinant human interferon α-2b gel as a treatment to chronic cervicitis and hence to reveal the feasibility of this kind of treatment method. Methods: One to three months treatment of using recombinant human interferon α-2b gel and consequent observation to the 268 patients (ages 20-50) suffered from different severities of chronic cervicitis (96 cases of mild severity, 120 of moderate and 52 of severe) were carried out during May 2005 to June 2010 in Guangzhou Dongsheng Hospital. Results: The short-term effective rate was 63.1％ according to the follow-up examination conducted one month after the treatment and the rate climbs to 81.7％ three months after the treatment, there was a significant difference both of them (ρ＜0.05), which indicated that the treatment was relatively effective as to the cases with mild to moderate symptoms but not with severe ones. Conclusion: The therapeutic effectiveness of the treatment of using the recombinant human interferon α-2b gel for chronic cervicitis is significant and the treatment should be elongated for the cases with severe symptoms to achieve a satisfactory therapeutic effectiveness.%目的:探讨重组人干扰素α-2b凝胶治疗慢性宫颈炎的治疗效果及其原因,以揭示运用重组人干扰素α-2b凝胶治疗该疾病的可行性.方法:通过对2005年5月～2010年6月来广州市东升医院就诊的268例20～50岁患有不同程度慢性宫颈炎的女性(轻度96例,中度120例,重度52例)应用重组人干扰素α-2b凝胶进行1～3个月的治疗效果观察.结果:用药治疗后1个月复查,其有效率为63.1%,用药3个月后复查,其有效率为81.7%,用药3个月后与1个月后有效率比较,差异有统计学意义(P<0.05).轻度及中度糜烂疗效较好,重度糜烂疗效较差.结论:重组人干扰素α-2b凝胶治疗慢性宫颈炎疗效是明显的,对于重度糜烂可以增加疗程以提高疗效.
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