目的 探讨高原肺动脉高压大鼠重返平原红细胞计数、肺动脉压力变化规律.方法 雄性Wistar大鼠在模拟海拔5 000 m低压低氧舱中形成肺动脉高压动物模型,待高原肺动脉高压模型形成后,迅速低转至平原,每10天随机抽取大鼠测定平均肺动脉压及血常规,分析其变化规律.结果 低压低氧第30天高原肺动脉高压、血红蛋白达到本试验最高值,重返平原后肺动脉压力与血红蛋白变化具有可逆性,但肺动脉高压下降时间晚于血红蛋白下降.结论 红细胞增多、血红蛋白增高可能是形成肺动脉高压的一个重要原因.%Objective To investigate the variation rule of red blood cell count and pulmonary arterial pressure after rats with pulmonary arterial hypertension returned to plain. Methods Male Wistar rats were made into animal model with pulmonary arterial hypertension in experimental cabin with low pressure and low oxygen simulating altitude of 5 000 m. After the animal models formed, they were returned to plain rapidly, and then their mean pulmonary arterial pressure and blood routine were determined every 10 days to analyze the variation rule. Results High plateau pulmonary arterial hypertension and hemoglobin reached the highest value in low-pressure and hypoxemia cabin after 30 days. The variation of pulmonary arterial pressure and hemoglobin was reversible after they returned to plain, but pulmonary hypertension fall time later than the fall time of hemoglobin. Conclusion An important cause of pulmonary hypertension may be the increase of erythrocyte and raise of hemoglobin.
展开▼
