阿立哌唑与奥氮平治疗老年期痴呆精神行为症状的效果观察

摘要

Objective To Investigate the clinical efficacy on senile dementia with behavioral and psychological symptoms in the treatment with Aripiprazole and Olanzapine. Methods 84 patients with senile dementia associated with behavioral and psychiatric symptoms were selected in the hospital from March 2009 to December 2011, who were divided into two groups randomly. 42 patients who used Olanzapine treatment were as the control group. 42 patients who used Aripiprazole in the treatment were as the observation group. The course of treatment was 8 weeks. After treatment of 1 weeks, 2 weeks, 4 weeks, 8 weeks, AD behavioral pathology In scale (BEHAVE-AD), treatment emergent symptom scale (TESS) of patients were performed. Before the treatment and after treatment of 8 weeks, minimum mental state examination was performed. Results After treatment, AD behavioral pathology in scale total score and each factor scores in the control group and observation group decreased significantly. The incidence rate of adverse drug reactions (19.0%) in the observation group was significantly lower than that In the control group (45.2%), the differences were statistically significant (P ＜ 0.05). Minimum mental state examination scores in the control group and observation group evaluated. Total efficiency of AD behavioral pathology In scale score and minimum mental state examination score In the observation group was slightly higher than those In the control group, while there were no significant differences between them (P ＞ 0.05}. Conclusion Aripiprazole and Olanzapine in the treatment of senile dementia with behavioral and psychological symptoms have equivalent clinical efficacy. But Aripiprazole has better security, which is more suitable for clinical use.%目的 探讨阿立哌唑与奥氮平治疗老年期痴呆的精神行为症状的临床疗效.方法 选取我院2009年3月~2011年12月收治的老年期痴呆伴精神行为症状患者84例,随机分为两组,采用奥氮平治疗患者42例为对照组,采用阿立哌唑治疗患者42例为观察组,疗程均为8周,于治疗后1、2、4、8周分别对患者进行阿尔茨海默病行为病理量表(BEHAVE-AD)、不良反应症状量表(TESS)测定,于治疗前和治疗8周后对患者进行简明精神状态检查表(MMSE)测定.结果 治疗后,对照组与观察组AD行为病理量表总评分和各因子均明显下降,观察组不良反应发生率(19.0%)明显低于对照组(45.2%),差异均有统计学意义(P<0.05).对照组与观察组简明精神状态检查表评分均略有升高,观察组AD行为病理量表评分和简明精神状态检查表评分总有效率均略高于对照组,差异均无统计学意义(P>0.05).结论 阿立哌唑和奥氮平用于治疗老年期痴呆伴精神行为症状的临床疗效相当,但阿立哌唑的安全性较好,更适合于临床使用.